Interleukin-1 and cognitive brain functions

Abstract


The cytokines of lnterleukin-1 family (IL-1α and β, IL-1 r.a., IL-18) play a key role in processes of neuroimmune interactions. Well known has been their role in regulation of motivational state and homeostatic functions (body temperature, HPA axis, and so on), in induction of prodromal syndrome's manifestations, in pathogenesis of a number of neural diseases. Present revue is dedicated to the aspects of neurobiology of IL-1 family investigated least of all their involvement into regulation of cognitive functions. Published data and results of our own studies proved the influence of IL-1α and β as well as IL-18 to education and memory processes, and revealed different character of the effects on individuals at early and maturate ages.

O E Zubareva

V M Klimenko

Email: klimenko_victor@mail.ru

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