Endothelial cell as a target of bacteria and their components



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This review highlights recent advances in the field of endothelial cells function during infection and inflammation. The primary function of endothelial cells during infection is to recognize pathogens and inflammatory stimuli from phagocytes. Endothelial cells exposed to pathogens induce an inflammatory response through different receptors including TLRs. TLRs expression has been demonstrated on various endothelial cells and significantly increases under inflammatory conditions. TLRs use different signaling pathways to trigger signals resulting in proinflammatory genes expression. Activated endothelial cells take part in the innate immune response with production of inflammatory cytokines and expression of adhesive molecules. T//s review is Reused on the role of activated endothelial cells in innate and adaptive immunity, inflammation, destruction of cells and angiogenesis. Much recent work shows that vascular inflammatory responses can be limited by anti-inflammatory mechanisms. It seems logical to look at endothelial cells as therapeutic targets when aiming at reestablis//ng normal immunity and resolve inflammation.

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I S Freidlin

Email: irinaf-n@yandex.ru

E A Starikova

References

  1. Быков В.Л. Цитология и общая гистология. СПб.: СОТИС, 1998. 519 с.
  2. Старикова Э.А., Соколов Д.И., Чернова A.A. и др. Влияние бактериальных лигандов паттерн распознающих рецепторов моноцитоподобных клеток ТНР-1 на их трансэндотелиальную миграцию // Мед. иммунол. 2008. Т. 10. № 6. С. 605-613.
  3. Старикова Э.А., Фрейдлин И.С., Соколов Д.И. и др. Изменения свойств эндотелиальных клеток линии EA.hy.926 под влиянием ТКТальфа, IFNraммa и IL-4 // Иммунология. 2005. № 2. С. 83-87.
  4. Старикова Э.А., Амчиславский Е.И., Соколов Д.И. и др. Изменения поверхностного фенотипа эндотелиальных клеток под влиянием провоспалительных и противовоспалительных цитокинов // Мед. иммунол. 2003. Т. 5. № 1-2. С. 39-48.
  5. Тотолян A.A., Фрейдлин И.С. Клетки иммунной системы. СПб.: Наука, 2000. Т. 1, 2. 231 с.
  6. Фрейдлин И.С., Шейкин Ю.А. Эндотелиальные клетки в качестве мишеней и продуцентов цитокинов // Мед. иммунол. 2001. Т. 3. № 4. С. 499-514.
  7. Чернова A.A., Старикова Э.А., Соколов Д.И. и др. Сравнительное изучение влияния продуктов бактериального происхождения на поверхностный фенотип.моноцитоподобных и эндотелиальных клеток // ЖМЭИ. 2008. № 4. С. 60-63.
  8. Ярилин A.A. Основы иммунологии. М.: Медицина, 1999. 608 с.
  9. Affara М., Dunmore В., Savoie Ch. et al. Understanding endothelial cell apoptosis: what can the transcriptome, glycome and proteome reveal? // P//l. Trans. R. Soc. B~ 2007. Vol. 362. P. 1469-1487.
  10. Akashi-Takamura S., Miyake K. TLR accessory molecules // Cur. Opin. Immunol. 2008. Vol. 20. P. 420-425.
  11. Arancibia S., Beltran C., Aguirre I. et al. Toll-like receptors are key participants in innate immune responses // Biol. Res. 2007. Vol. 40. P. 97-112.
  12. Atkinson T. Toll-like receptors, transduction-effector pathways, and disease diversity: evidence of an immunobiological paradigm explaining all human illness? // Int. Rev. Immunol. 2008. Vol. 27. P. 255-281.
  13. Bowdish D., Loffredo M., Mukhopadhyay S. et al. Macrophage receptors implicated in the «adaptive» form of innate immunity // Microbes and Infection. 2007. Vol. 9. № 14-15. P. 1680-1687.
  14. Brindle N.P.J. Growth factors in endothelial regeneration // Cardiovasc. Res. 1993. Vol. 27. P. 1166-1172.
  15. Bums E., Marsiel A., Musser J. Activation of a 66-Kilodalton Human endothelial Cell Matrix Metalloprotease by Streptococcus pyogenes Extracellular Cysteine Protease // Infect, and Immun. 1996. Vol. 64. №11. p. 4744-4750.
  16. Catravas J., Callow A., Ryan U., Simionescu M. Vascular endothelium. Source and target of inflammatory mediators // NATO Science Seriees 1. 2001. Vol. 330. IOS Press, Amsterdam. 397 p.
  17. Cattaruzza M., Slodowski W., Stojakovic M. et al. Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cell // J. Biol. Chem. 2003. Vol. 278. № 39. P. 37874-37880.
  18. Cines D., Poliak E., Buck C. et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders // Blood. 1998. Vol. 91. P. 3527-3561.
  19. Curtiss L., Tobias P. Emerging role of toll-like receptors in atherosclerosis // J. Lipid. Res. 2008. Vol. 49. № 10. P. 2113-2123.
  20. Cuzzola M., Mancuso G., Beninati C. et al. β2 Integrins Are Involved in Cytokine Responses to Whole Gram-Positive Bacterial // J. Immunol. 2000. Vol. 164. P. 5871-5876.
  21. Damas I., Jensenius M., Ueland T. et al. Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in pathogenic interaction between Rickettsia africae, endothelial cells, and platelets // J. Immunol. 2006. Vol. 177. P. 2699-2706.
  22. Danese S., Dejana E., Fiocchi C. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation // J. Immunol. 2007. Vol. 178. P. 6017-6022.
  23. Devaraj S., Davis B., Simon S.I. CRP promotes monocyte-endothelial cell adhesion via Fey receptors in human aortic endothelial cells under static and shear flow conditions //Am. J. Physiol. Heart. Circ. Physiol. 2006. Vol. 29. P. 1170-1176.
  24. Doran K., Engelson E., Khosravi A. et al. Blood-brain barrier invasion by group В Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid // J. Clin. Invest. 2005. Vol. 115. № 9. P. 2499-2507.
  25. Dunzendorfer S., Lee H., Tobias P. Flow-dependent regulation of endothelial Toll-like receptor 2 expression through in//bition of SP1 activity // Circ. Res. 2004. Vol. 95. P. 684-691.
  26. Erridge C., Spickett C., Webb D. Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2 // Cardiovasc. Res. 2007. Vol. 73. P. 181-189.
  27. Faure E., Equils O., Sieling P. et al. Bacterial lipopoly-saccharide activates NFkB through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells // J. Biol. Chem. 2000. Vol. 275. P. 11058-11063.
  28. Fitzner N., Clauberg S., Essmann F. et al. Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands // Clin, and Vac. Immunol. 2008. Vol. 15. № 1. P. 138-146.
  29. Fumitaka S., Yoshihiro S., Shoji K. et al. Dynamics of immunoglobulins at the feto-matemal interface // Rev. of Reprod. 1999. Vol. 4. P. 81-89.
  30. Gerasimovskaya E.V., Woodward H.N., Tucker D.A. et al. Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells // Angiogenesis. 2008. Vol. 11. № 2. P. 169-182.
  31. Groger M., Sarmay G., Fiebiger E. et al. Dermal microvascular endothelial cells express CD32 receptors in vivo and in vitro // J. Immunol. 1996. Vol. 156. P. 1549-1556.
  32. Gupta D., Wang Q., Vinson Ch. et al. Bacterial peptidoglican induces CD 14-dependent activation of transcription factors CREB/ATF and AP-I // J. Biol. Chem. 1999. Vol. 274. №20. P. 14012-14020.
  33. Gustavsson A., Armulik A., Brakebusch C. et al. Role of the bl-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia // J. Cell Sei. 2002. Vol. 115. P. 2669-2678.
  34. Hamann A. Engelhardt В. Leukocyte trafficking. GmH. W1LEI-VCH Veglag, 2005. 625 p.
  35. Heidemann J., Ruther C., Kebschull M. et al. Expression jfIL-12-related molecules in human intestinal microvascular endothelial cells is regulated by TLR3 // Am. J. Physiol. Gastroint. Liv. Physiol. 2007. Vol. 293. P. 1315-1324.
  36. Imaizumi T., Yoshida H., Nishi N. et al. Double-stranded RNA induces gaIectin-9 in vascular endothelial cells: involvement of TLR3, P13K, and 1RF3 pathway //Glicobiology. 2007. Vol. 17. P. 12-15.
  37. Kawai T., Akira Sh. TLR signaling // Seminars in Immunol. 2007. Vol. 19. P. 24-32.
  38. Khreiss T., Jozsef L., Potempa L.A. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells // Circulation. 2004. Vol. 109. P. 2016-2022.
  39. Kotowicz K., Callard R. E., Friedrich K. et al. Biological activity of 1L-4 and IL-13 on human endothelial cells: functional evidence that both cytokines act through the same receptor // Intern. Immunol. Vol. 8. № 12. P. 1915-1925.
  40. La Sala A., Ferrari D., Di Virgilio F. et al. Alerting and turning the immune response by extracellular nucleotides // J. Leukoc. Biol. 2003. Vol. 73. P. 339-343.
  41. Lee M.S., Kim Y. Pattern-recognition receptor signaling initiated from extracellular membrane and cytoplasmic space // Mol. Cells. 2007. Vol. 23. № 1. P. 1-10.
  42. Lentschat A., Karahashi H., Michelsen K. et al. Mas-toparan, G protein agonist peptide, differentially modulates TLR4 and TLR2-mediated signaling in human endothelial cells and murine macrophages // J. Immunol. 2005. Vol. 174. P. 4252-4261.
  43. Li J., Ma Z., Tang Z. et al. CpG DNA-mediated immune response in pulmonary endothelial cells // Am. J. Physiol. Lung. Cell. Mol. Physiol. 2004. Vol. 287. P. L552-L558.
  44. Makrides S.С. Therapeutic In//bition of the Complement System // Pharmacol. Rew. Vol. 50. № 1. P. 245-259.
  45. Mantovani A., Bussolino F., Martino I. Cytokine regulation endothelial cell function: from molecular level to bedside // Immunol. Today. 1997. Vol. 1. P. 231-239.
  46. Marin V., Montero-Julian F.A., Gres S. The lL-6-solu-ble lL-6Ra autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin // J. Immunol. 2001. Vol. 167. P. 3435-3442.
  47. McClenahan D., Hellenbrand K., Atapattu D. et al. Effects of lipopolysaccharide and Mannheimia haemoiytica leukotoxin on bovine lung microvascular endothelial cells and alveolar epithelial cells // Clin. and Vaccine Immunol. 2008. Vol. 15. P. 338-347.
  48. Mehta J. L., Chen J., Hermonat P. L., Romeo F. et al. Lectin-like, oxidized low-density lipoprotein receptor-l(LOX-l): A critical player in the development of atherosclerosis and related disorders // Cardiovasc. Res. 2006. Vol. 69. P. 36-45.
  49. Moreland J., Bailey G. Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent //Am. J. Physiol. Lung. Cell. Mol. Physiol. 2006. Vol. 290. P. 833-840.
  50. Murdoch C., Finn A. Chemokine receptors and their role in vascular biology // J. Vase. Res. 2000. Vol. 37. P. 1-7.
  51. Netea M., van der Graaf Ch., van der Meer J. et al. Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system // J. Leukoc. Biol. 2004. Vol. 75. №3. P. 749-755.
  52. Nijhuis C., Vellenga E., Daenen S. et al. Endothelial cells are main producers of interleukin 8 through Tolllike receptor 2 and 4 signaling during bacterial infection in leukopenic cancer patients // Clin. Diagnost. Lab. Immunol. 2003. Vol. 10. P. 558-563.
  53. Nobbs A., Lamont R., Jenkinson H. Streptococus adherence and colonization // Microbiol. and Molecular. Biol. Rev. 2009. Vol. 9. P. 407-450.
  54. Noonan D., Barbara A., Vannini N. et al. Inflammation, inflammatory cells and angiogenesis: decisions and indecisions // Cancer Metastas. Rev. 2008. Vol. 27. P. 31-40.
  55. O’Neill L. When signaling pathways collide: positive and negative regulation of Toll-like receptor signal transduction // Immunity. 2008. Vol. 29. № 7. P. 12-23.
  56. O’Neill L., Bowie A. The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling // Nat. Rev. Immunol. 2007. Vol. 7. № 5. P. 353-364.
  57. Opitz B., Forster S., Hocke A. et al. Nodi-mediated endothelial cell activation by Chlamydop//la pneumoniae // Circ. Res. 2005. Vol. 96. P. 319-326.
  58. Pan L., Kreisle R., Shi Y. Detection of Fey receptors on human endothelial cells stimulated with cytokines tumor necrosis factor-alpha (TNFα and interferon-gamma (IFNγ) // Clin. Exp. Immunol. 1998. Vol. 112. P. 533-538.
  59. Pegu A., Qin S., Junecko B. et al. Human lymphatic endothelial cells express multiple functional TLRs // J. Immunol. 2008. Vol. 180. P. 3399-3405.
  60. Peters K., Unger R., Drunner J. et al. Molecular basis of endothelial dysfunction in sepsis // Cardiovasc. Res. 2003. Vol. 60. P. 49-57.
  61. Saadi S., Wrenshall L.E., Platt J.L. Regional manifestation and control of the immune system // FASEB. 2002. Vol. 16. №6. P. 849-856.
  62. Santos-Sierra S., Golenbock D., Henneke Ph. Toll-like receptor-dependent discrimination of streptococci // J. of Endotoxin. Res. 2006. Vol. 12. № 5. P. 307-312.
  63. Schwiebert L.M., Rice W.C., Kudlow B.A. et al. Extracellular ATP signaling and P2X nucleotide receptors in monolayer of primary human vascular endothelial cells // Am. J. Physiol. Cell. Physiol. 2002. Vol. 282. № 2. P. 289-301.
  64. Silverstein Roy L. and Febbraio Maria. CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior // Sci. Signal. 2009. Vol. 2. P. 3.
  65. Stinson M., Alder S., Kumar S. Invasion and killing of human endothelial cells by viridans group Streptococci // Infect, and Immun. 2003. Vol. 71. № 5. P. 2365-2372.
  66. Strasly M., Cavallo F., Geuna M. et al. IL-12 Inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk // J. Immunol. 2001. Vol. 166. P. 3890-3899.
  67. Tafazolli F., Holmstrom A., Forsberg et al. Apically exposed, tight junction-associated bl-integrins allow binding and yopE-mediated perturbation of epithelial barriers by wild-type Yersinia bacteria // Infect. and Immun. 2000. Vol. 68. № 9. P. 5335-5343.
  68. Taylor P.R., Martinez-Pomares L., Stacey M. et al. Macrophage receptors and immune recognition // Annu. Rev. Immunol. 2005. Vol. 23. P. 901-944.
  69. Tedgui A., Mallat Z. Anti-inflammatory mechanisms in vascular wall // Circ. Res. 2001. Vol. 88. P. 877-887.
  70. Terpstra D.V., van Amersfoort E. S., van Velzen A. G. et al. Hepatic and Extrahepatic Scavenger Receptors: Function in Relation to Arteriosclerosis // Thromb. Vase. Biol. 2000. Vol. 20. P. 1860-1872.
  71. Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence // Immunology. 2007. Vol. 7. P. 179-190.
  72. Van Maren W., Jacobs J., de VriesJ. et al. Toll-like receptor signaling on Tregs: to suppress or not to suppress? // Immunology. 2008. Vol. 124. P. 445-452.
  73. Wang H., Akinci I., Baker Ch. et al. The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death // J. Immunol. 2007. Vol. 179. P. 1834-1841.
  74. Wehner J., Morrell C.N., Reynolds T.B. et al. Antibody and complement in transplant vasculopathy // Circ. Res. 2007. Vol. 100. P. 191-203.
  75. Yarokopakis E., Albzrech M., Martin M. et al. TLR2 transmodulates monocyte adhesion and transmigration via Racland РІЗК-mediated inside-out-signaling in response to Porphyromonas gingivalis fimbriae // J. Immunol. 2006. Vol. 176. P. 7645-7656.
  76. Yazdankhah S.P. and Caugant D.A. Neisseria meningitidis: an overview' of the carriage state // J. Med. Microbiol. 2004. Vol. 53. P. 821-832.
  77. Yeh Ch., Chen J., Chia J. Glucosyltransferases of viridans group Streptococci modulate Interleukin-6 and adhesion molecule expression in endothelial cells and augment monocytic cell adherence // Infect, and Immun. 2006. Vol. 74. № 2. P. 1273-1283.
  78. Yumoto H., Chou H., Takahashi Y. et al. Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-Like receptor 4 by bacterial fimbria-dependent invasion // Infect, and Immun. 2005. Vol. 73. P. 8050-8059.
  79. Zeukea S., Ulmerb A., Kusumoto Sh. et al. TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS // Cardiovasc. Res. 2002. Vol. 56. P. 126-134.
  80. Zhang X., Mosser D.M. Macrophage activation by endogenous danger signals // J. Pathol. 2008. Vol. 214. P. 161 - 178.

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