Endothelial cell as a target of bacteria and their components

Abstract


This review highlights recent advances in the field of endothelial cells function during infection and inflammation. The primary function of endothelial cells during infection is to recognize pathogens and inflammatory stimuli from phagocytes. Endothelial cells exposed to pathogens induce an inflammatory response through different receptors including TLRs. TLRs expression has been demonstrated on various endothelial cells and significantly increases under inflammatory conditions. TLRs use different signaling pathways to trigger signals resulting in proinflammatory genes expression. Activated endothelial cells take part in the innate immune response with production of inflammatory cytokines and expression of adhesive molecules. T//s review is Reused on the role of activated endothelial cells in innate and adaptive immunity, inflammation, destruction of cells and angiogenesis. Much recent work shows that vascular inflammatory responses can be limited by anti-inflammatory mechanisms. It seems logical to look at endothelial cells as therapeutic targets when aiming at reestablis//ng normal immunity and resolve inflammation.

I S Freidlin

Email: irinaf-n@yandex.ru

E A Starikova

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