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Antiviral activity of adamantane derivatives against respiratory syncytial virus
- Authors: Shtro A.A.1, Galochkina A.V.1, Nikolaeva Y.V.1, Garshinina A.V.1, Razgulyaeva D.N.1, Ponomarev K.Y.2, Mozhaytsev E.S.2, Suslov E.V.2, Volcho K.P.2, Salakhutdinov N.F.2
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Affiliations:
- Smorodintsev Research Institute of Influenza
- N.N. Vorozhtzov Novosibirck Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
- Issue: Vol 22, No 2 (2022)
- Pages: 115-123
- Section: Original research
- URL: https://journals.eco-vector.com/MAJ/article/view/108808
- DOI: https://doi.org/10.17816/MAJ108808
- ID: 108808
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Abstract
BACKGROUND: Respiratory syncytial infection annually affects large segments of the population around the world. Despite the ease of clinical manifestations in most adults, for children under two years of age, this disease is a serious danger, leading to the development of severe bronchiolitis, even death.
AIM: The aim of this study was to search for drugs with antiviral activity among adamantane derivatives.
MATERIALS AND METHODS: Preparations of the group of adamantane derivatives were synthesized in the Department of Medicinal Chemistry of Natural Compounds of the N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS. The cytotoxicity and antiviral activity of the compounds were studied in HEp-2 cell culture using the MTT test and enzyme immunoassay, respectively.
RESULTS: There were no drugs with high antiviral properties against RSV in this group.
CONCLUSIONS: Despite the absence of drugs with pronounced anti-RSV properties, the information obtained in the course of the work can be used for a targeted search for antitumor substances.
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About the authors
Anna A. Shtro
Smorodintsev Research Institute of Influenza
Author for correspondence.
Email: aashtro@gmail.com
ORCID iD: 0000-0002-2295-1881
SPIN-code: 3184-7395
Cand. Sci. (Biol.), Head of the Laboratory of Chemotherapy for Viral Infections
Russian Federation, Saint PetersburgAnastasiya V. Galochkina
Smorodintsev Research Institute of Influenza
Email: nastyagalochkina@yandex.ru
ORCID iD: 0000-0002-3208-8006
SPIN-code: 1257-5625
Cand. Sci. (Biol.), Leading Research Associate, Laboratory of Chemotherapy for Viral Infections
Russian Federation, Saint PetersburgYulia V. Nikolaeva
Smorodintsev Research Institute of Influenza
Email: yuilia.nikolaeva@influenza.spb.ru
ORCID iD: 0000-0001-6396-3144
Cand. Sci. (Biol.), Leading Research Associate, Laboratory of Chemotherapy for Viral Infections
Russian Federation, Saint PetersburgAnzhelika V. Garshinina
Smorodintsev Research Institute of Influenza
Email: anzhelika.garshinina@influenza.spb.ru
Research Associate, Laboratory of Chemotherapy for Viral Infections
Russian Federation, Saint PetersburgDaria N. Razgulyaeva
Smorodintsev Research Institute of Influenza
Email: drazgulyaeva@bk.ru
ORCID iD: 0000-0003-1468-117X
Laboratory Assistant, Laboratory of Intracellular Signaling and Transportа
Russian Federation, Saint PetersburgKonstantin Yu. Ponomarev
N.N. Vorozhtzov Novosibirck Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: ponomarev@nioch.nsc.ru
ORCID iD: 0000-0002-8324-4208
Cand. Sci. (Chem.), Research Associate, Laboratory of Directed Transformations of Natural Compounds
Russian Federation, NovosibirskEvgeny S. Mozhaytsev
N.N. Vorozhtzov Novosibirck Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: mozh@nioch.nsc.ru
ORCID iD: 0000-0002-5344-9499
Cand. Sci. (Chem.), Research Associate, Laboratory of Directed Transformations of Natural Compounds
Russian Federation, NovosibirskEvgeny V. Suslov
N.N. Vorozhtzov Novosibirck Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: suslov@nioch.nsc.ru
ORCID iD: 0000-0003-0988-0502
SPIN-code: 2483-1228
Cand. Sci. (Chem.), Head of the Laboratory of Directed Transformations of Natural Compounds, Deputy Director for Research
Russian Federation, NovosibirskKonstantin P. Volcho
N.N. Vorozhtzov Novosibirck Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: volcho@nioch.nsc.ru
ORCID iD: 0000-0002-4083-9324
SPIN-code: 1026-0466
Scopus Author ID: 6603712204
Dr. Sci. (Chem.), Professor, Chief Research Associate, Laboratory of Physiologically Active Substances
Russian Federation, NovosibirskNariman F. Salakhutdinov
N.N. Vorozhtzov Novosibirck Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: anvar@nioch.nsc.ru
ORCID iD: 0000-0001-8512-4309
Dr. Sci. (Chem.), Head of the Laboratory of Physiologically Active Substances
Russian Federation, NovosibirskReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).