NON-MOTOR SYMPTOMS AND QUALITY OF LIFE IN PATIENTS WITH ESSENTIAL TREMOR, PARKINSONS DISEASE AND THE COMBINATION OF ESSENTIAL TREMOR AND PARKINSONS DISEASE

  • Authors: Kudrevatykh AV1,2, Didur MD3, Sergeev T.V1, Bug DS2, Miliukhina IV1,2,4
  • Affiliations:
    1. FSBEI Institute of Experimental Medicine”
    2. FSBSI “Pavlov First St. Petersburg State Medical University” of the Ministry of Health of the Russian Federation
    3. FSBIE Institute of Human Brain of the Russian Academy of Science”
    4. FSBEI “Petersburg Nuclear Physics Institute”
  • Issue: Vol 18, No 2 (2018)
  • Pages: 63-71
  • Section: Articles
  • URL: https://journals.eco-vector.com/MAJ/article/view/10920
  • DOI: https://doi.org/10.17816/MAJ18263-71
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Abstract


Aim of the study: to assess non-motor symptoms and quality of life in patients with essential tremor (ET), different stages of Parkinson’s Disease (PD) and combination of ET and PD (ET-PD). Materials and methods of the research: We examined 82 patients with ET, 20 patients with ET-PD, 283 patients with PD, and 72 neurologically healthy volunteers. The neuropsychological status, intensity of motor symptoms, the grade of vegetative dysfunction and dyssomnia, and quality of life of patients were assessed. Results: Patients with ET showed wide range of nonmotor symptoms. The severity of cognitive impairment in group of patients with ET corresponded with the same severity of patients with early stages of PD. It is interesting that patients with ET showed more severe depression than patients with early stages of PD. The maximum severity of anxiety-depressive disorders was observed in patients with the combination of ET-PD. Conclusion: In spite of the fact that it is usual to consider the ET as a monosymptomatic benign disease, we have found significant non-motor disorders in this group of patients and a significant violation of the quality of life. The results of the study also give evidence that patients with ET-PD represent a special group of patients, characterized by special, both motor and non-motor symptoms. The data we obtained made it possible to form a deeper understanding of the generality of the clinical manifestations of ET, PD and ET-PD, which will make it possible to improve the quality of management of patients with these nosologies in clinical practice.

A V Kudrevatykh

FSBEI Institute of Experimental Medicine”; FSBSI “Pavlov First St. Petersburg State Medical University” of the Ministry of Health of the Russian Federation

M D Didur

FSBIE Institute of Human Brain of the Russian Academy of Science”

TV V Sergeev

FSBEI Institute of Experimental Medicine”

D S Bug

FSBSI “Pavlov First St. Petersburg State Medical University” of the Ministry of Health of the Russian Federation

I V Miliukhina

FSBEI Institute of Experimental Medicine”; FSBSI “Pavlov First St. Petersburg State Medical University” of the Ministry of Health of the Russian Federation; FSBEI “Petersburg Nuclear Physics Institute”

  1. Lombardi W.J., Woolston D.J., Roberts J.W., Gross R.E. Cognitive deficits in patients with essential tremor // Neurology. 2001. Vol. 57, No 5. Р. 785-790.
  2. Critcley E. Clinical manifestations of essential tremor // J. Neurol. Neurosurq Psychiatry. 1972. Vol. 35, No 3. Р. 365-372
  3. Louis E, Diaz D, Kuo S, Gan S, Cortes E, Vonsattel J. et al. Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor // Cerebellum & Ataxias. 2018. Vol. 5. Р. 1.
  4. Klaming R., Annese J. Functional anatomy of essential tremor: lessons from neuroimaging // Am. J. Neuroradiol. 2014. Vol. 35, No 8. Р. 1450-1457.
  5. Rajput A., Rozdilsky B., Ang L., Rajput A. Significance of parkinsonian manifestations in essential tremor // Can. J. Neurol. Sci. 1993. Vol. 20, No 2. Р. 114-117.
  6. Ozen Barut B, Gunal D, Turkmen 3., Mollahasanoglu A., Ankarali H. Clinical and cognitive profiles of patients with both Parkinson’s disease and essential tremor // Acta Neurologica Belgica. 2012. Vol. 113. Р. 117-125.
  7. Louis E, Wise A., Alcalay R, Rao A., Factor-Litvak P. Essential tremor-Parkinsons disease: A double whammy // Journal of the Neurological Sciences. 2016. Vol. 366. Р. 47-51.
  8. Postuma R.B. et al. MDS clinical diagnostic criteria for Parkinson's disease // Movement Disorders. 2015. Vol. 30, No 12. Р. 1591-1601.
  9. Deuschl G, Bain P, Brin M. Consensus Statement of the Movement Disorder Society on Tremor // Movement Disorders. 2008. Vol. 13. Р. 2-23.
  10. Sengul Y, Sengul H., Sural M., Bakim B, Forta H. Comparison between rate of nonmotor symptom development in essential tremorand Parkinson's disease // Acta Neurol. Belg. 2015. Vol. 115, No 3. Р. 289-294.
  11. Tombaugh T., McIntyre N. The mini-mental state examination: a comprehensive review // J. Am. Geriatr. Soc. 1992. Vol. 40, No 9. Р. 922-935.
  12. Nazem S, Siderowf A, Duda J., Ten Have T, Colcher A, Horn S. et al. Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with a «normal» - global cognition according to mini-mental state examination score // Journal of the A merican G eriatrics Society. 2009. Vol. 57. Р. 304-308.
  13. Slachevsky A, Villalpando J., Sarazin M, Hahn-Barma V., Pillon B, Dubois B. Frontal Assessment Battery and Differential Diagnosis of Frontotemporal Dementia and Alzheimer Diseas // Archives of Neurology. 2004. Vol. 61, No 7. Р. 1104-1107.
  14. Obeso I., Casabona E, Bringas M, Elvarez L, Jahanshahi M. Semantic and Phonemic Verbal Fluency in Parkinson’s D isease: Influence of Clinical and Demographic Variables // Behavioural Neurology. 2012. Vol. 25. Р. 111-118.
  15. Kick S, Bell J., Norris J., Steiner J. Validation of two anxiety scales in a university primary care clinic // Psychosomatic Medicine. 1994. Vol. 56. Р. 570-576.
  16. Snaith R. The Hospital Anxiety and Depression Scale // Psychiatric Bulletin. 1992. Vol. 16. Р. 451.
  17. Krnrner A., Lauritzen L, Abelskov K, Gulmann N, Brodersen M.A., Wedervang-Jensen T. et al. The Geriatric Depression Scale and the Cornell Scale for Depression in Dementia. A validity study // Nordic Journal of Psychiatry. 2006. Vol. 60. Р. 360-364.
  18. Rabin R, Charro F. EQ-SD: a measure of health status from the EuroQol Group // Annals of Medicine. 2001. Vol. 33. Р. 337-343.
  19. Tryster A., Pahwa R., Fields J., Tanner C, Lyons K. Quality of life in Essential Tremor Questionnaire (QUEST): Development and initial validation // Parkinsonism & Related Disorders. 2005. Vol. 11. Р. 367-373.
  20. Thanawattano C., Anan C., Pongthornseri R., Dumnin S., Bhidayasiri R. Temporal fluctuation analysis of tremor signal in Parkinson's disease and Essential tremor subjects // Conf Proc IEEE Eng Med Biol Soc. 2015. Р. 6054-6057.
  21. Иллариошкин С., Иванова-Смоленская И. Дрожа2ельные гисеркинезы. М.: Изд. Холд. А2-мос-ера, 2011. 360 с. [Illarioshkin S., Ivanova-Smolenskaya I. Tremulous hyperkinesis. Moscow: Izd. Hold. Atmosphera, 2011. 360 p.]
  22. Bermejo-Pareja F. Essential tremor - a neurodegenerative disorder associated with cognitive defects? // Nat. Rev. Neurol. 2011. Vol. 7, No 5. Р 273-282.
  23. Thawani S., Schupf N., Louis E. Essential tremor is associated with dementia: prospective populationbased study in New York // Neurology. 2009. Vol. 73, No 8. Р. 621-625.
  24. Shill H., Hentz J., Jacobson S., Belden C., Sabbagh M., Beach T. et al. Essential Tremor in the Elderly and Risk for Dementia // Journal of Neurodegenerative Diseases. 2014. Vol. 2014. Р. 1-5.
  25. Benito-Leyn J., Mato-Abad V., Louis E., Hern6ndez-Tamames J., Elvarez-Linera J., Bermejo-Pareja F. et al. White matter microstructural changes are related to cognitive dysfunction in essential tremor // Scientific Reports. 2017. Vol. 7, No 1. Р. 2978.
  26. Chen J., Yao J., Wu Y., Chen Y., Mao C., Liu C. Cognitive dysfuctions associated with essential tremor and Parkinson's disease // Zhonghua Yi Xue Za Zhi. 2014. Vol. 94, No 31. Р. 2412-2416.
  27. Левин О., Македонский П., Смоленуева И., Лычева Н. Нейроссихологические нарушения у больных с эссенциальным 2ремором // Неврологический журнал. 2005. No 4. С. 25-33. [Levin O., Makedonsky P., Smolentseva I. Lycheva N. Neuropsychological Journal. 2005, No 4, рр. 25-33].
  28. Lee S., Kim M., Lee H., Kwon K., Koh S. Nonmotor symptoms in essential tremor: Comparison with Parkinson's disease and normal control // Journal of the Neurological Sciences. 2015. Vol. 349. Р. 168-173.
  29. Thenganat M.A., Jankovic J. The relationship between essential tremor and Parkinson's disease // Parkinsonism & related disorders. 2016. Vol. 1. Р. 162-165.
  30. Giorelli M., Bagnoli J., Consiglio L., Lopane M., Bosco Zimatore G., Zizza D. et al. Do nonmotor symptoms in Parkinson's disease differ from essential tremor before initial diagnosis? A clinical and scintigraphic study // Parkinsonism & Related Disorders. 2014. Vol. 20. Р. 17-21.
  31. Louis E. Essential tremor: from bedside to bench and back to bedside // Curr. Opin. Neurol. 2014. Vol. 27, No 4. Р. 461-467.
  32. Benito-Leyn J., Alvarez-Linera J., Hernandez-Tamames J., Alonso-Navarro H., Jimenez-Jimenez F., Louis E. Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla // Journal of the Neurological Sciences. 2009. Vol. 287. Р. 138-142.
  33. Hanajima R. Pathophysiology of tremor rhythm // Rinsho Shinkeigaku. 2013. Vol. 53. Р. 1276- 1278.
  34. Benito-Leyn J. Essential tremor: one of the most common neurodegenerative diseases? // Neuroepidemiology. 2011. Vol. 36, No 2. Р. 77-78.
  35. Louis E, Vonsattel J. The emerging neuropathology of essential tremor // Movement Disorders. 2007. Vol. 23. Р. 174-182.
  36. Louis E.D., Faust P.L., Vonsattel J.P., Honig L.S., Rajput A., Robinson C.A. et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls // Brain. 2007. Vol. 130. P. 3297-3307.
  37. Louis E, Frucht S. Prevalence of essential tremor in patients with Parkinson's disease vs. Parkinson-plus syndromes // Movement Disorders. 2007. Vol. 22. Р. 1402-1407.

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Copyright (c) 2018 Kudrevatykh A.V., Didur M.D., Sergeev T.V., Bug D.S., Miliukhina I.V.

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