The effect of chronic emotional and physical stress on the neuroendocrine and immune systems

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Abstract

The aim of the presented study was to characterize the developed model of chronic stress. Most of the currently existing models of chronic stress are long, laborious, hard to employ, and also difficult to reproduce, which leads to restrictions in their use. Daily swimming in cold water for 10 days model was proposed as a model of chronic stress. The described influence led to a significant involution of the thymus, an increase in the expression of the interleukin-4 (IL-4) and interleukin-6 (IL-6) genes in the thymus, and its decrease in the hypothalamus, a change in behavioral reactions, as well as a multiple increase in the blood concentration of corticosterone in the experimental animals. The data suggest that repeated swimming in cold water in experimental animals causes changes in the activity of the hypothalamic-pituitary-adrenal system, the immune system, and also demonstrate the possibility of using the presented model as a model of chronic stress.

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About the authors

Irina A. Yankelevich

Institute of Experimental Medicine; Saint Petersburg State Chemical Pharmaceutical University

Author for correspondence.
Email: rina.yankelevich@pharminnotech.com
SPIN-code: 9249-6844

PhD in Biological Sciences, Senior Research Fellow, Assistant Professor

Russian Federation, Saint Petersburg

Tatyana A. Filatenkova

Institute of Experimental Medicine; Saint Petersburg State Chemical Pharmaceutical University

Email: lero269@gmail.com
SPIN-code: 4198-3636

Research Fellow

Russian Federation, Saint Petersburg

Mark V. Shustov

Saint Petersburg State Chemical Pharmaceutical University

Email: shustovmark99@gmail.com

Student

Russian Federation, Saint Petersburg

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2. Fig. 1. The concentration of corticosterone (nmol/L) in the serum of experimental animals not exposed to stress, as well as after the application of chronic stress. * p < 0.05 in compare with intact animals

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3. Fig. 2. The mass of the thymus of animals after applying the model of chronic stress. * p < 0.05 in compar with intact animals

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4. Fig. 3. Expression of the genes IL-4 (a) and IL-6 (b) in the thymus of experimental animals that were not subjected to stress, as well as after the application of chronic stress. *p < 0.05 in compare with control animals

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5. Fig. 4. Expression of the IL-4 (a) and IL-6 (b) genes in the hypothalamus of experimental animals not subjected to stress, as well as after the application of chronic stress. * p < 0.05 in compare with control animals

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Copyright (c) 2019 Yankelevich I.A., Filatenkova T.A., Shustov M.V.

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