The role of cell proliferation in atherogenesis and in the destabilization of atherosclerotic plaque in human

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Abstract

The review examined of the processes of cell proliferation in human vascular wall and experimental animals during the formation of atherosclerotic plaques. Shows the types of actively proliferating cells: lymphocytes, macrophages, endotheliocytes and zones identified in the vascular wall, where this proliferation occurs. The factors that promote and hinder cell proliferation during the growth of atherosclerotic plaque are identified. The survey shows all the stages of the formation of atherosclerotic lesions, ranging from normal plots and lipid stains to pronounced fibrous plaques. Establishes a link between the cell proliferation and inflammation in the vascular wall man. Separately considered the role of cell proliferation in the destabilization of atherosclerotic plaque. If atherosclerosis this process still poorly studied, in the formation of unstable atherosclerotic plaques in humans it is completely unknown. Based on your own original data was finally on the important role of the processes of cell proliferation in the formation of unstable atherosclerotic plaques in humans.

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About the authors

Peter V. Pigarevsky

Institute of Experimental Medicine

Author for correspondence.
Email: pigarevsky@mail.ru
ORCID iD: 0000-0002-5906-6771
SPIN-code: 8636-4271

PhD (Biology), Head, Department of General Morphology

Russian Federation, Saint Petersburg

Olga G. Yakovleva

Institute of Experimental Medicine

Email: pigarevsky@mail.ru
ORCID iD: 0000-0002-6248-9468

Researcher Associate, Department of General Morphology

Russian Federation, Saint Petersburg

Svetlana V. Maltseva

Institute of Experimental Medicine

Email: pigarevsky@mail.ru

PhD (Biology), Researcher Associate, Department of General Morphology

Russian Federation, Saint Petersburg

Veronica A. Guseva

Institute of Experimental Medicine

Email: pigarevsky@mail.ru

PhD (Biology), Researcher Associate, Department of General Morphology

Russian Federation, Saint Petersburg

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2. Fig. 1. Cellular proliferation in various types of atherosclerotic lesions in human (a, b, c, d — an immunoperoxcidase method on PCNA identification-positive cells by means of monoclonal antibodies. ×750): a — numerous proliferating mononuclear (m) and smooth muscule (d′) cells in a cap of unstable atherosclerotic plaque; b — in the destructive cap of unstable atherosclerotic plaque numerous proliferating lymphocytes (1) and macrophages (2) are visible; c — the proliferating smooth muscule cells which are located on border of media and adventitia under a stable atherosclerotic plaque; d — lack of a proliferation in the dense fibrous cap of a stable atherosclerotic plaque

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Copyright (c) 2019 Pigarevsky P.V., Yakovleva O.G., Maltseva S.V., Guseva V.A.

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