SOLUBLE FORMS OF IMMUNE CHECK-POINT RECEPTOR PD-1 AND ITS LIGAND PD-L1 IN PERIPHERAL BLOOD OF ONCOLOGIC PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS

A A Alferov; Алферов А А; E S Gershtein; Герштейн Е С; D S Naberezhnov; Набережнов Д С; I O Goryatcheva; Горячева И О; N E Kushlinskii; Кушлинский Н Е

SOLUBLE FORMS OF IMMUNE CHECK-POINT RECEPTOR PD-1 AND ITS LIGAND PD-L1 IN PERIPHERAL BLOOD OF ONCOLOGIC PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS

Authors: Alferov AA¹, Gershtein ES¹, Naberezhnov DS¹, Goryatcheva IO¹, Kushlinskii NE¹
Affiliations:
1. N.N. Blokhin National Medical Research Center of Oncology
Issue: Vol 19, No 1S (2019)
Pages: 8-9
Section: Articles
Published: 15.12.2019
URL: https://journals.eco-vector.com/MAJ/article/view/19293
ID: 19293

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Abstract

The levels proteins of control points of immunity sPD-1, sPD-L1 in serum or plasma of 366 patients with malignant tumors of various nosological forms treated at the N.N. Blokhin National Medical Research Center of Oncology. A correlation of sPD-L1 with the prevalence of the process and the degree of tumor malignancy, as well as a positive correlation with some other tumor markers of blood, was found: VEGF, VEGFR1, MMP-7, MMP-8, TIMP-1.

Keywords

sPD-L1, sPD-1, VEGF, VEGFR1, MMP-7, MMP-8, TIMP-1, sPD-1, sPD-L1, VEGF, VEGFR1, MMP-7, MMP-8, TIMP-1, kidney cancer, ovarian cancer, gastric cancer, bone sarcomas, blood serum, blood plasma