THYMIC STRESS-INDUCED ATROPHY AND MAST CELLS

Abstract

In a study using histological methods, the dynamics of thymic mast cells was evaluated in response to the administration of hydrocortisone to white outbred mice. It was established that 48 hrs after the administration of the hormone, the number of mast cells increases 10-fold, while cells appear at all stages of maturation. In parallel, the level of mast cell degranulation increases. Maturation of mast cells within the thymus and their participation in the regulation of cell migration and remodeling of the extracellular matrix under stress is assumed.