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Evaluating of prognostic value of biomarker and upper reference limit calculating
- Authors: Bunenkov N.S.1, Bunenkova G.F.1, Komok V.V.1, Grinenko O.A.1, Nemkov A.S.1
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Affiliations:
- Pavlov First Saint Petersburg State Medical University
- Issue: Vol 20, No 2 (2020)
- Pages: 79-86
- Section: Lecture
- URL: https://journals.eco-vector.com/MAJ/article/view/26271
- DOI: https://doi.org/10.17816/MAJ26271
- ID: 26271
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Abstract
Objective: to develop algorithm of assessment of prognostic value of biomarker (troponin I) for predicting death after coronary artery bypass grafting.
Materials and methods. Data collection was performed according to prospective non-randomized clinical trial AMIRI — CABG in Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia between 2016–2019 years with 336 patients. There is database with clinical, laboratory and instrumental data. Statistics were calculated with SAS Enterprise Guide 6.1 software. Prognostic capability of biomarker for death were evaluated with logistic regression. Spline of relation between death and biomarker level were plotted using coefficient of logistic regression and intercept. Upper reference limit was calculated with Youden index.
Results. There was developed algorithm to assess prognostic value of biomarker and its usefulness for clinical application and to define upper reference limit of biomarker. This algorithm could be useful for physicians and researchers for data analysis.
Conclusion. Presented algorithm of data analysis allows to assess prognostic value of novel biomarker and its clinical usefulness.
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About the authors
Nikolay S. Bunenkov
Pavlov First Saint Petersburg State Medical University
Author for correspondence.
Email: bunenkov2006@gmail.com
ORCID iD: 0000-0003-4331-028X
PhD student, Department of Faculty Surgery
Russian Federation, Saint PetersburgGulnara F. Bunenkova
Pavlov First Saint Petersburg State Medical University
Email: gulnara533@gmail.com
resident, Department of Hospital Therapy
Russian Federation, Saint PetersburgVladimir V. Komok
Pavlov First Saint Petersburg State Medical University
Email: vladimir_komok@mail.ru
ORCID iD: 0000-0002-3834-7566
SPIN-code: 3572-5180
PhD, cardiac surgeon, Department of Cardiac Surgery No. 2
Russian Federation, Saint PetersburgOleg A. Grinenko
Pavlov First Saint Petersburg State Medical University
Email: klinika@spb-gmu.ru
MD, vice-rector
Russian Federation, St. PetersburgAlexander S. Nemkov
Pavlov First Saint Petersburg State Medical University
Email: nemk_as@mail.ru
ORCID iD: 0000-0002-5152-0001
SPIN-code: 2853-4634
Doctor of Medical Science, Professor, Cardiac Surgeon, Department of Cardiac Surgery No. 2
Russian Federation, Saint PetersburgReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).