Clinical and neurophysiological peculiarities of tumor-related epilepsy

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Abstract

Detection and correction of structural tumor-associated epilepsy remain relevant at the present time. Seizures occur in 75–90% of cases in patients with gliomas of malignancy’s various degrees.

The aim of this work was to clarify the links of pathogenesis and clinical and neurophysiological features of structural epilepsy in intracerebral tumors.

Materials and methods. We examined 23 patients with intracerebral tumors and symptomatic epilepsy.

Results. Epileptiform activity was registered in 2 or more regions in more than half of the patients — 12 people (52.18%), and 7 of them (58.3%) it spread to neighboring leads. No association was found between the size of the tumor and the number of attacks.

Conclusions. Grade I–II tumors predominate among patients with tumor-related epilepsy. In this population with a high frequency after surgery, both tumor control and freedom from seizures can be achieved. It is necessary to manage this group of patients after surgery with regular neurophysiological monitoring (MRI, positron-emission tomography and video-EEG monitoring) to correct antiepileptic therapy and maintain a high level of quality of life.

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About the authors

Nadezhda V. Tolstykh

N.P. Beсhtereva Institute of the Human Brain of the Russian Academy of Sciences

Author for correspondence.
Email: zaratustra-e@yandex.ru
ORCID iD: 0000-0003-4403-8783

neurologist, office neurology of Outpatient Advisory Department

Russian Federation, Saint Petersburg

Alexander F. Gurchin

N.P. Beсhtereva Institute of the Human Brain of the Russian Academy of Sciences

Email: agurchin@gmail.com

candidate of medical Sciences, neurosurgeon, senior researcher of the Laboratory of Neuroimaging

Russian Federation, Saint Petersburg

Nadezhda Yu. Koroleva

N.P. Beсhtereva Institute of the Human Brain of the Russian Academy of Sciences

Email: koroleva.ny@gmail.com

the Head of the office of neurology of Outpatient Advisory Department, junior researcher of the Laboratory of Stereotactic Methods

Russian Federation, Saint Petersburg

Igor D. Stolyarov

N.P. Beсhtereva Institute of the Human Brain of the Russian Academy of Sciences

Email: sid@ihb.spb.ru
ORCID iD: 0000-0001-8154-9107

MD, PhD, DSci (Medicine), Professor, the Head of the Laboratory of Neuroimmunology

Russian Federation, Saint Petersburg

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Supplementary files

Supplementary Files
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2. Fig. 1. The distribution of the patients according to the degree of anaplasia

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3. Fig. 2. The distribution of the patients with tumors on the duration of disease in months before surgery

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4. Fig. 3. Wake. The sensitivity is 50 mсV/cm. Sharp waves and deformed “sharp-slow wave” complexes with an amplitude of up to 45 mсV in the right parietal-central region

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5. Fig. 4. Second sleep cycle. Non-REM sleep. Second stage. The sensitivity is 70 mсV/cm. In the right temporal region, there are discharges of “sharp-slow wave” complexes, with a maximum of T4, with an amplitude of up to 85 mсV

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6. Fig. 5. First sleep cycle. Non-REM sleep. Second stage. The sensitivity is 70 mсV/cm. In the right temporal region, lateralized discharges of “sharp-slow wave” complexes, with a maximum of T4, with an amplitude of up to 105 mсV

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7. Fig. 6. Second sleep cycle. Non-REM sleep. Second stage. The sensitivity is 70 mсV/cm. In the structure of physiological sleep phenomena (K-complex), a diffuse discharge of “sharp-slow wave” complexes with an amplitude of up to 205 mсV

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8. Fig. 7. The distribution of the patients by tumor location

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9. Fig. 8. The distribution of the patients with intracerebral tumors by the number of taken PEP

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Copyright (c) 2020 Tolstykh N.V., Gurchin A.F., Koroleva N.Y., Stolyarov I.D.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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