Immune mechanisms in atherosclerosis

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Abstract

Nowadays it’s widely accepted that inflammation plays a pivotal role in atherosclerotic plaque development and destabilization. In present review we present our results of analysis of intercellular adhesion molecular, cytokines and blood lipids in patients with ischemic heart disease. Taken the role of immunity in atherogenesis, we report data on influence of lovastatin on inflammatory markers in patients with stable angina. Using the model of hypercholesterolemic mice (Арое–/–) with hyperactive T-lymphocytes we discuss the role of inflammatory mediators of plaque stability.

About the authors

N. A. Yaitsky

I. P. Pavlov State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, Saint Petersburg

Е. V. Shlyakhto

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, Saint Petersburg

N. N. Petrischev

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

N. A. Gavrisheva

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

G. K. Hansson

Karolinska Institute

Email: shabanov@mail.rcom.ru
Sweden, Stockholm

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