Coronary atherosclerosis and cytokines

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Abstract

It is established, that in development of a coronary atherosclerosis, participate the immune-mediated mechanisms. In blood of patients with coronary atherosclerosis the maintenance of the basic classes of cytokines (IL-1β, IL-2, IL-6, IL-8, TNF-α) is increased. Development of acute coronary insufficiency is accompanied by additional increase of levels of the data cytokines. The accessory of the cytokine activity to a coronary atherosclerosis is confirmed at studying the maintenance mRNA cytokines in a vascular wall. Thus, in a zone atheromatous (aorta) it is synthesized mainly mRNA IL-2, while in a zone lipomatosis (a beam artery) it is formed nonspecific immune reaction with development of the mRNA IL-1 and IL-6.

It is shown, that for patients with rheumatoid arthritis typically more active defeat of a coronary arteries, in comparison with healthy persons. Chronic immune-mediated process in frameworks of the autoimmune pathology can serve a trigger for accelerated development ischemic heart disease.

General immune-inflammatory mechanisms participating in pathogenesis of the ischemic heart disease and rheumatoid arthritis, allow to spend the certain parallels between atherosclerotic process and autoimmune pathology.

About the authors

S. V. Stolov

Medical Academy of Postgraduate Education

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

V. I. Mazurov

Medical Academy of Postgraduate Education

Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, Saint Petersburg

V. A. Yakusheva

Medical Academy of Postgraduate Education

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

I. A. Ivanova

Medical Academy of Postgraduate Education

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

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