Роль интерферонов I типа в регуляции иммунной системы

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Аннотация

Интерфероны (IFN) I типа - группа цитокинов, которая все еще продолжает расширяться за счет открытия новых членов. В обзоре приводятся данные о недавно открытых членах семейства (IFN-каппа и -лямбда). Рассматриваются характеристики рецепторов для IFN I класса и основные пути проведения сигнала, запускаемые взаимосвязью молекул IFN с рецепторами. Анализируются механизмы, активируемые IFN при защите от вирусных и бактериальных инфекций. Рассматривается связь интерферонов с другими цитокинами в различных иммунных реакциях, регуляция активности молекулами интерферонов иммунокомпетентных клеток и роль IFN-a/p в иммунном надзоре над опухолями.

Об авторах

Н. Б. Серебряная

ГосНИИ особо чистых биопрепаратов

Автор, ответственный за переписку.
Email: shabanov@mail.rcom.ru
Россия, Санкт-Петербург, 197110, ул. Пудожская, 7

С. А. Кетлинский

ГосНИИ особо чистых биопрепаратов

Email: shabanov@mail.rcom.ru
Россия, Санкт-Петербург, 197110, ул. Пудожская, 7

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