Complex assessment of cardioprotective actions of ischemic preconditioning: the influence of ischemia severity on the antiarrhythmic effect

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Abstract

A protective effects of ischemic preconditioning (IPC) on subsequent prolonged myocardial ischemic/reperfusion damage were investigated using both in vivo rat model and isolated heart preparation. Myocardial infarct size, severity and duration of ischemia- and reperfusion-induced arrythmias, and a rate of intraischemic and postischemic contractile recovery were used as an end points of myocardial protection. Accordingly, two major aspects of cardioprotection afforded by IPC could be specified as antiarrythmic and infarct-limiting, i.e., antiischemic. A threshold of antiarrythmic effect of IPC appears to be lower than that of infarct-limiting potency. We failed to see any protection against reperfusion-induced arrythmias when coronary flow was reduced more then two-fold from its initial value. In contrast, IPC confers more early and complete intraischemic contractile recovery in the presence of severe reduction in coronary flow.

About the authors

N. N. Petrishchev

I.P. Pavlov Federal Medical University

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

V. A. Tsirlin

I.P. Pavlov Federal Medical University

Email: medaj@eco-vector.com

Research Institute of Cardiology of the Ministry of Health Care

Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

T. D. Vlasov

I.P. Pavlov Federal Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

A. V. Syrensky

I.P. Pavlov Federal Medical University

Email: medaj@eco-vector.com

Research Institute of Cardiology of the Ministry of Health Care

Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

D. L. Sonin

I.P. Pavlov Federal Medical Universi

Email: medaj@eco-vector.com

 

 

Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

S. M. Minasian

I.P. Pavlov Federal Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

M. M. Galagudza

I.P. Pavlov Federal Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197022, 6/8 Lva Tolstogo St.

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