The IL-17 family cytokines and it biological function

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Abstract

Twelve years ago IL-17 was discovered as a proinflammatory cytokines that are produced by memory cells. The six members of IL-17A-F family possesses by many functions so as supporting of tissue homeostasis, defend organism from pathogenic microbes, participate in regulation of neutrophils quantity in peripheral blood and in CD417 development.

However cytokines of IL-17 family play roles in pathogenesis of allergic, autoimmune diseases and in transplantats rejections.

About the authors

S. A. Ketlinskiy

SSC RF «Institute high pure biopreparations» FMBA

Author for correspondence.
Email: shabanov@mail.rcom.ru

Член-корреспондент РАМН

Russian Federation, St. Petersburg

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