Email this article Modulation of the reinforcing effects of psychotropic drugs by means of corticoliberin
- Authors: Shabanov P.D.1, Lebedev A.A.1, Rusanovsky V.V.1, Pavlenko V.P.1
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Affiliations:
- Military Medical Academy
- Issue: Vol 6, No 2 (2006)
- Pages: 54-59
- Section: Basis medicine
- Published: 18.05.2006
- URL: https://journals.eco-vector.com/MAJ/article/view/693578
- ID: 693578
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Abstract
Amphetamine (1 mg/kg), morphine (1 mg/kg) and ethaminal-natrium (5 mg/kg) activated, but astressin (1 µg/pl), a nonselective antagonist of corticoliberin receptors, administered intraamygdaloidally, depressed selfstimulation reaction of lateral hypothalamus in rats. The blockade of extrahypothalamic (in the central nucleus of amygdala) corticoliberin receptors by means of astressin changed the effects of different narcogens on self-stimulation reaction. On that background, amphetamine did not activate self-stimulation, ethaminal-natrium supported the significant psychoactivative effect, but morphine changed its stimulating effect on depressant one. Leu-enkephalin possessed the stable depresssant effect, strengthening the action of astressin. Perhaps, the strengthening of depressant action of leu-enkephalin on self-stimulation by means of astressin is associated with temporary excluding of activative influence of the central nucleus of amygdala on hypоthalamus.
About the authors
P. D. Shabanov
Military Medical Academy
Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
A. A. Lebedev
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
V. V. Rusanovsky
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
V. P. Pavlenko
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).