Tree types of lymphozytes biochemical response to infections process

Our studies of lymphocyte metabolism in infections diseases with children enabled us to determine 3 major types of biochemical response to infections process based on the intensify of the lipid peroxidation (LPO) in lymphocytes.

Type 1 - LPO processes are suppressed in lymphocytes (low N-25, 2 folds decrease in DK level). Bactericide defence is unsufficient despite of the marked adaptive metabolic activation (5-6 folds growth of ACTH and STH concentrations; 2,5 fold growth in cyclic nucleotides). Low interferon blood lewels are observed. Complications are quit frequent as well as the occurence of the secondary bacterial infections; the process often is seen getting chronic. Antioxidant therapy is not recommended.

Type 2 - LPO activation within physiological limits (high N+25; 2-2,5 folds growth in DK level). Respiratory burst developing in the acute phase of the disease provides a bactericide effect. Moderate adaptive activation of both metabolism and interferonogenesis result in quite speedy reconvalescence without any complications and chronisation double effect vitamin-antioxidant therapy (for example vitamin C) is the most desirable.

Type 3 - Hyperactivation of LPO in lymphocytes (DK is much higher than normal >4 N; 8-10 folds growth in DK level), evidences the developmentof patologic disorders in LPO and is followed by crucial changes in biochemical parametres as well as by membrane damage. The patients are observed to have suppressed interferonogenesis and superinfections. Severe inflammatorycomplications and intoxiction are frequent with these patients. These patients shuld have special antioxidant therapies.