Influence of Baclofen and Valproat on background and evoked activity of the trigeminal nucleus caudalis neurons on the craniovascular pain’s model

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Abstract

Efficacy of the GABA-ergic drugs in prophylactic treatment of migraine and chronic daily headache is a well-known fact and is an indirect evidence of GABA’s role in the pathogenesis of primary cephalgias. At the same time, there are only few experimental trials on the GABA-ergic drugs studying their mechanism of action in craniovascular pain and the results are contradictory.

The influence of Baclofen (i.v.) in doses 2.5; 5; 10 and 15 mg/kg and Valproat (i. v.) in doses 25; 50; 100 and 200 mg/kg on background and evoked by electrical stimulation of the dura mater activity of the trigeminal nucleus caudalis neurons was investigated in series of acute experiments on rats. It was shown, that Baclofen and Valproat reduce background and evoked activity of trigeminal complex neurons in dose- dependent manner, and that is an experimental evidence of potential central mechanism of action of the GABA-positive drugs in vascular headaches.

About the authors

A. Yu. Sokolov

Pavlov State Medical University

Author for correspondence.
Email: medaj@eco-vector.com

Valdman Institute of Pharmacology

Russian Federation, St. Petersburg, 197089

A. V. Amelin

Pavlov State Medical University

Email: medaj@eco-vector.com

Valdman Institute of Pharmacology

Russian Federation, St. Petersburg, 197089

Yu. D. Ignatov

Pavlov State Medical University

Email: medaj@eco-vector.com

Valdman Institute of Pharmacology

Russian Federation, St. Petersburg, 197089

S. S. Panteleev

Pavlov Institute of Physiology of Russian Academy of Sciences

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 199034

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