Effect of М- and N-cholinolytics on the brain prenatal monoaminergic system development

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Abstract

Prenatal cholinergic drug exposure produced dramatic imbalance of the neurotransmitter contents and turnover in the rat fetus brain on the 20th day of pregnancy. The comparative analysis showed that the serotoninergic neurotransmitter system was more sensitive to influence of cholinolytics in prenatal period than dopaminergic system. Decreasing of 5-HT concentration and its turnover in all «critical periods» on the second half of pregnancy was marked under influence as metamizil, and gangleron, the M- and N-cholinolytics respectively. Whereas the brain dopaminergic system of genotypical males and famales embryos was more sensitive to influence N-cholinotropic drug gangleron. Thus, prenatal influence of cholinotropic drugs on pregnant females resulted in sex-linked alterations of brain dopaminergic and serotoninergic systems at 20-day’s old fetuses of rats. These alterations can be involved to ethiopathogenesis of behavioral dysfunctions of rats progenies in pubertal period and be connected with deviated behavior.

About the authors

A. A. Bairamov

I. P. Pavlov State Medical University of St. Petersburg

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197022

N. S. Sapronov

Institute for Experimental Medicine of the RAMS

Email: medaj@eco-vector.com

член-корреспондент РАМН

Russian Federation, St. Petersburg, 197376

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