Apoptosis and its role in atherogenesis

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Abstract

Modified low density lipoproteins and obligate parasites, playing very important role in the development of immune inflammation under atherogenesis, activate apoptosis of arterial cells intima during the most initial stages of the development of atherosclerotic damages of blood vessels. Apoptosis of arterial cell walls fulfills both negative role, producing cell death and promoting thromboses formation, and positive role as an integral protective-adjustment process, activating phagocytes and controlling cell proliferation. Peroxidemodified low density lipoproteins (mLDL), especially including into an immune complex one, not are cytotoxic for macrophages, but at the same time are the main cause of their apoptosis. Apoptosis of macrophages, smooth muscle cells and endotheliocytes under atherogenesis can be induced both mLDL, and cell reactions, going with the development of immune inflammation into the zone of atherosclerotic damages of arteries.

About the authors

V. A. Nagornev

Institute of Experimental Medicine of the RAMS

Author for correspondence.
Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, St. Petersburg, 197376

A. N. Voskanianz

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376

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