The role of lipoprotein lipase activity, hyperinsulinemia and free fatty acid concentration in genesis of dislipidemias

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Abstract

We studied fasting insulin concentrations, free fatty acids (FFA) and glucose level in plasma and postheparin lipoprotein lipase activity in patients with combined dislipidemia (DLP) and hypertriglyceridemia (HTG). The subjects with combined DLP or HTG had increased plasma insulin level (11,62±1,36 mU/ml, p<0,001; 12,21 ±2,13 mU/ml, p<0,001 v.s. 5,01 ±0,51 mU/ml), FFA level (0,87+0,07 mmol/l, p<0,001; 0,65+0,07 mmol/l, p<0,05 v.s. 0,49±0,04 mmol/l) and high body weight compared with the control persons. The HTG patients characterised by decreased lipoprotein lipase activity in postheparin plasma (5,57±0,98 mmol/l/h v.s. 9,03±0,71 mmol/l/h; p<0,01) too. We observed the significant relationships between fasting concentrations of TG, FFA, insulin in plasma and body mass index in all patients.

Obviously the some part of combined DLP and HTG phenotypes result from metabolic syndrome and have the like biochemical mechanisms that differ no more.

About the authors

Yu. V. Frolova

Institute of Experimental Medicine of the RAMS

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. V. Ageeva

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

T. V. Vinogradova

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

I. A. Oleinik

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

O. Yu. Zdanova

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

N. S. Zaitzeva

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

N. M. Kalashnikova

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

A. D. Denisenko

Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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