Email this article The yield of chromosome aberrations in lymphocytes as а marker of sick rate in human
- Authors: Vorobtsova I.Е.1, Semenov А.V.1
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Affiliations:
- Central Research lnstitute of Rontgenology and Radiology
- Issue: Vol 8, No 4 (2008)
- Pages: 45-49
- Section: Basis medicine
- Published: 27.11.2008
- URL: https://journals.eco-vector.com/MAJ/article/view/693913
- ID: 693913
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Abstract
People exposed to low-dose ionizing radiation due to Chernobyl accident, nuclear bomb testing, occupational exposure (in total 370 persons) were investigated on the yield of unstable (conventional method) and stable (FISH method) chromosome aberrations in their lymphocytes. The correlation between the frequency of these aberrations and risk of various somatic diseases in given group was studied. For this whole people sample was subdivided in to the 2 groups - with "high" and "low" levels of investigated parameter values. ln group with the high level of unstable and stable chromosome aberrations the incidence of cardiovascular diseases were significantly increased as compared to the group with the low level of these chromosome damages. The prognostic possibilities of different types of cytogenetic endpoints is discussed.
About the authors
I. Е. Vorobtsova
Central Research lnstitute of Rontgenology and Radiology
Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg
А. V. Semenov
Central Research lnstitute of Rontgenology and Radiology
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg
References
- Мельнов С.Б. Молекулярно-генетические эффекты экологического неблагополучия. Минск, 2004.
- Bauchinger М., Schmid Е., Zitzelsberger Y. et al. Radiation-induced chromosome aberrations analyzed by two-color fluorescence in situ hybridization with composite whole chromosome-specific DNA probes and а pancentromeric DNA probe // lnt. J. Radiat. Biol. 1993. Vol. 64. Р. 179-184.
- Biological dosimetry: Chromosomal aberration analysis for dose assessment // IAEA. Technical report series №260. 1986. Vienna.
- Bonassi S., Hagmar L., Stromberg И. et al. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens // Cancer Res. 2000. Vol. 60. Р. 1619-1625.
- Hagmar L., Brogger А., Hansteen I.-L. et al. Cancer risk in human predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage // Cancer Res. 1994. Vol. 54. Р. 2919-2922.
- Ivanov V., Тsиb А., Ivanov S., Pokrovsky. Medical Radiological Consequences of the Chemobyl Catastrophe in Russia. St. Р.: Nauka, 2004.
- Lucas J.N., Awa А., Straume Т. et al. Rapid translocation frequency analysis in human decades after exposure to ionizing radiation // lnt. J. Radiat. Biol. 1992. Vol. 62. Р. 53-63.
- Smerhovsky Z., Landa К., Rosser Р. et al. Risk of cancer in an occupational exposed cohort with increased level of chromosomal aberrations // Environ. Health. Perspect. 2001. Vol. 109. Р. 41-45.
- Tucker J.D., Preston R.J. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment // Mutat. Res. 1996. Vol. 365. Р. 147-159.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).