Genetic basis of the attenuation of cold-adapted influenza viruses

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Abstract

In this review our own results and published data of contribution of single mutant genes in attenuation of live reassortant cold-adapted influenza vaccine were summarized. The critical role of genes coding for polymerase genes of A and В influenza viruses in attenuation was demonstrated.

About the authors

I. V. Kiseleva

Research Institute of Experimental Medicine of the RAMS

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

N. V. Larionova

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. P. Grigorieva

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

L. G. Rudenko

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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