The effect of modern influenza epidemics on population pneumonia mortality

Influenza epidemics influence on community-acquired and nosocomial pneumonia mortality among St. Petersburg adults aged 30 years and older in 1993-2004 was evaluated by prepared with methods of correlation and regression analysis (ARIMA model). Correlation between weekly morbidity and mortality (for autopsy data) data among adult was determined in the most of years. Excess mortality was maximal in influenza epidemics caused by antigenically different drift-variant subtype A(H3N2) and type В viruses and was minimal in epidemics caused by subtype A(H1 N1) influenza virus. For community-acquired pneumonia increase of excess mortality was observed in relationship with increasing of age of adults (age groups 30-39,40-49, 50-59, 60-69 70 years and older), excess mortality of males was higher than females in each age group. These findings were not observed for nosocomial pneumonia. Excess mortality for nosocomial pneumonia was reliably lower, than for community-acquired pneumonia.