Thyroid-stimulating hormone as neurohormone and neuromodulator

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Abstract

The article gives a review of the questions of expression and biosynthesis of biological active thyroid- stimulating hormone (TSH), its oc- and P-subunits. The structure, localization and expression regulation of mRNA of TSH a- and P-subunits are examined. Great attention is given to the distribution of TSH within CNS, as well as to hormonal and neurotransmitter regulation of secretion and biosynthesis of TSH and its subuints mRNA. Moreover, the structure of TSH receptors, their expression, localization and regulation are described.

About the authors

N. S. Sapronov

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Author for correspondence.
Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, St. Petersburg

Y. О. Fedotova

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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