Email this article The antiinflammatory, antinociceptive and gastroprotective effects of peptidoleukotriene receptor blockers
- Authors: Marusova I.В.1, Marusov I.V.1, Ignatov Y.D.1, Petrishchev N.N.1
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Affiliations:
- The State Pavlov Medical University
- Issue: Vol 2, No 4 (2002)
- Pages: 13-17
- Section: Basis medicine
- Published: 21.10.2025
- URL: https://journals.eco-vector.com/MAJ/article/view/693999
- ID: 693999
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Abstract
The role of peptidoleukotrienes and their receptors in the inflammatory pain and rheumatoid arthritis oedema is steel unclear and has to be investigated. Also it has been revealed in the limited reports that peptidoleukotrienes may participate in the pathogenesis of aspirin-induced gastrotoxicity. In our experiments on rats using the method of adjuvant-induced arthritis it has been shown that peptidoleukotriene receptor blockers montelukast sodium and zafirlukast produced antiinflammatory action (reduction of oedema) and antinociceptive effect (elevation of pain thresholds in the hot plate method). Used drugs had no effects in the tail-flick method. In experiments with montelukast it also has been shown that the drug reduced the ulcerative action of aspirin in stomach. The role of peptidoleukotrienes and their receptors in the regulation of inflammatory pain thresholds and aspirin-induced gastrotoxicity is discussed.
About the authors
I. В. Marusova
The State Pavlov Medical University
Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
I. V. Marusov
The State Pavlov Medical University
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
Y. D. Ignatov
The State Pavlov Medical University
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
N. N. Petrishchev
The State Pavlov Medical University
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).