Distribution of allele genes determining the development of trombophylia in men suffered from myocardial infarction in young age

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Abstract

The main goal of the present study was to evaluate the genetic impact of some genes operating in coagulation system in the development of the inherited predisposition to myocardial infarction (MI) in young men before 45 year old. For this purpose, we investigated the allele distribution of the 7 following genes: F V Leiden, F2 G20210A, G/A-455 FGB, GP IIIa PIA1/A2, A1/A2 5’F7, 4G/5G PAI-1, C677T MTHFR. The significant prevalence of PIA2 GP IIIa frequency in the patients with MI compared with controls was found (16,2% and 9,8%, respectively, p<0,05). The allele frequencies of other investigated genes were not different in patients and control group. This results allowed us to make a conclusion that the inherited predisposition to MI depends on platelet function whenever the clotting factors have a little impact on genetic predisposition to MI in young men before 45 year old.

About the authors

O. V. Sirotkina

Konstantinov Institute of Nuclear Physics of RAS

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, Gatchina

A. M. Sheidina

Konstantinov Institute of Nuclear Physics of RAS

Email: medaj@eco-vector.com
Russian Federation, Gatchina

M. V. Volkova

Konstantinov Institute of Nuclear Physics of RAS

Email: medaj@eco-vector.com
Russian Federation, Gatchina

O. A. Berkovich

I. P. Pavlov State Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

E. A. Bazhenova

I. P. Pavlov State Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

D. V. Cherkashin

Military-Medical Academy

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

S. A. Boitsov

Military-Medical Academy

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

E. V. Shlyakhto

I. P. Pavlov State Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

E. I. Schwarz

Konstantinov Institute of Nuclear Physics of RAS; I. P. Pavlov State Medical University

Email: medaj@eco-vector.com
Russian Federation, Gatchina; St. Petersburg

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Copyright (c) 2004 Sirotkina O.V., Sheidina A.M., Volkova M.V., Berkovich O.A., Bazhenova E.A., Cherkashin D.V., Boitsov S.A., Shlyakhto E.V., Schwarz E.I.


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