Primary and secondary skin damages in CD30+ lymphoproliferative disorders

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Abstract

Management of patients with CD30+ lymphoproliferative disorders varies from observations in case of relatively asymptomatic, spontaneously remitting disease (as in lymphomatoid papulosis) to multiagent chemotherapy regimens (as in disseminated CD30+ lymphoma), and the diagnosis requires the application of modern diagnostic tools. In our retrospective study two dermatopathologists independently reviewed 18 cases of CD30+ cutaneous lymphomas to determine the significance of each diagnostic methods. The study was carried out in four independent review sessions consisting of (1) review of histological sections only, (2) review of immunohistological sections, (3) introduction of the detailed clinical data and the history of disease, and (4) introduction of the outcome. Agreement with consensus was analyzed for every session and kappa statistics were calculated to evaluate the interobserver reliability. The results of our study show that the diagnosis of CD30+ cutaneous lymphomas has to be based on clinicopathologic correlation.

About the authors

A. V. Samtsov

Russian Military Medical Academy

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

I. E. Belousova

Russian Military Medical Academy

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

D. V. Kazakov

University Hospital, Zurich

Email: medaj@eco-vector.com
Switzerland, Zurich

V. Kempf

University Hospital, Zurich

Author for correspondence.
Email: medaj@eco-vector.com
Switzerland, Zurich

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Copyright (c) 2004 Samtsov A.V., Belousova I.E., Kazakov D.V., Kempf V.


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