Molecular and genetic mechanisms of atherosclerosis and ischemic heart disease

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Abstract

We genotyped polymorphisms from candidate genes in a prospective cohort of male patients (<=45 years old) for association with early-onset myocardial infarction in a case-control study (study 279 cases, 203 con­trols).

We tested single-nucleotide polymorphisms -455 G/A in fibrinogen gene, 4G/5G (-675 position) in plas- minogene activator inhibitor 1 gene, A1166C in gene of type 1 receptor of angiotensine II, G-6A in angiotensinogen gene, Sst I in apolipoprotein CIII gene, l/D polymorphism in angiotensin-converting enzyme gene, restrictive polymorphism in apolipoprotein E gene, PIA2 in platelet llb/llla receptor gene.

Results show that the PIA2 allele of platelet glycoprotein receptor llb/llla is a risk factor of young myocar­dial infarction in males and that carrying of PIA2/A2 genotype is a risk factor of sudden death because of thrombosis of coronary artery.

About the authors

О. A. Berkovich

I. P. Pavlov State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

Е. A. Bazhenova

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

Е. V. Volkova

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

N. V. Khromova

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

О. D. Belayeva

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

О. I. Ignatyeva

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

V. I. Larionova

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. V. Shlyakhto

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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Copyright (c) 2007 Berkovich О.A., Bazhenova Е.A., Volkova Е.V., Khromova N.V., Belayeva О.D., Ignatyeva О.I., Larionova V.I., Shlyakhto E.V.


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