Vol 7, No 3 (2007)

The review article present an analysis of conceptual and methodological tendencies in working up biliary ducts iatrogenic injuries problem. On the basis of using traditional and modern methods presented rational diagnostic algorithm, determinated optimized surgical tactics necessity.

Immediate and long-term treatment results of patients with biliary ducts iatrogenic injuries confirm the Fedorov’s clinic conceptual positions, accentuated necessity of combination principles biliary surgery and modern medical technologies abilities.

The antihypoxic effect of reamberine was shown on the model of rat sharp histotoxic hypoxia produced by the respiration blocker sodium fluoride. This effect was more evident as compared with GOBA. The anti- ischemic activity of reamberine was displayed on the early stage of myocardium ischemia. In the model of the liver toxic damage the hepatoprotective action of reamberine was found out. It may be compared with carsil.

This randomized controlled phase II study evaluated the efficacy of neoadjuvant chemotherapy (doxoru­bicin + paclitaxel) compared with endocrine treatment with aromatase inhibitors (anastrazole or exemestane) in postmenopausal women with ER-positive and/or PgR-positive breast cancer. Preoperative neoadjuvant endocrine therapy with aromatase inhibitors was well tolerated and resulted in similar rates of overall objec­tive response and breast-conserving surgery as chemotherapy in postmenopausal women with ER-positive and/or PgR-positive tumors.

243 isolates of Mycobacterium tuberculosis (116 - drug-sensitive (DS), 127 - multidrug-resistant (MDR)) were investigated. 44 isolates from newly diagnosed patients (13 - DS, 31 - MDR) were genotyped. Fast (less than 30 days) and massive (more than 100 colonies) growth was 10 times more prevalent in MDR than DS strains. The Beijing genotype stains prevailed (about 90%) among MDR isolates. 92,3% of DS isolates had non-Beijing genotypes. The data obtained proved the epidemic spread of MDR-ТВ in Karelia.

30-years experience in the field of health study of several thousand of workers employed in various national economy branches and exposed to adverse working conditions, using a unified technique, is sum­marized. Evidence on significant prevalence of occupational diseases and their structure are obtained. Methods of their prediction and objective registration adequate for different countries are suggested.

Sergey Petrovich Botkin is a famous clinician and teacher, the founder of the national scientific medicine, the creator of the fist Russian and one of the earliest world scientific therapeutic schools. Upon Botkin’s initiative new clinics of infectious diseases, dermatology and venerology diseases, otorinolaringology were founded. Botkin was the outstanding public statesmen, the chief of Russian medical society, one of the initiators of women high medical education in Russia. The article is dedicated to 175 years birthday of S. R Botkin.