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Optimization of M2e cassette amino acid composition for the development of universal influenza vaccine
- Authors: Mezhenskaya D.А.1, Isakova-Sivak I.N.1, Katelnikova A.E.2, Rudenko L.G.1
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Affiliations:
- Institute of Experimental Medicine
- Institure of Preclinical Research
- Issue: Vol 21, No 3 (2021)
- Pages: 127-130
- Section: Conference proceedings
- URL: https://journals.eco-vector.com/MAJ/article/view/76326
- DOI: https://doi.org/10.17816/MAJ76326
- ID: 76326
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Abstract
The development of a universal influenza vaccine with a wide spectrum and duration of action is one of the serious public health problems. This study is dedicated to optimization of an immunogen covering the M2e epitopes of influenza A viruses circulating in the natural reservoir, as well as the creation of a prototype of a universal influenza vaccine with subsequent quantitative and qualitative assessment of the induced anti-M2e responses in ferrets.
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About the authors
Daria А. Mezhenskaya
Institute of Experimental Medicine
Author for correspondence.
Email: dasmez@iemspb.ru
ORCID iD: 0000-0001-6922-7682
SPIN-code: 5799-8802
Junior Reseacher of Laboratory of Immunology and Prevention of Viral Infections, A.A. Smorodintsev Department of Virology
Russian Federation, Saint PetersburgIrina N. Isakova-Sivak
Institute of Experimental Medicine
Email: isakova.sivak@gmail.com
ORCID iD: 0000-0002-2801-1508
SPIN-code: 3469-3600
Dr. Sci. (Biol.), Head of Laboratory of Immunology and Prevention of Viral Infections, A.A. Smorodintsev Department of Virology
Russian Federation, Saint PetersburgAnastasiya E. Katelnikova
Institure of Preclinical Research
Email: katelnikova.ae@doclinika.ru
ORCID iD: 0000-0003-3203-9869
SPIN-code: 7473-6070
PhD
Russian Federation, Leningrad Region, KuzmolovskyLarisa G. Rudenko
Institute of Experimental Medicine
Email: vaccine@mail.ru
ORCID iD: 0000-0002-0107-9959
SPIN-code: 4181-1372
Dr. Sci. (Med.), Professor, Head of the A.A. Smorodintsev Department of Virology
Russian Federation, Saint PetersburgReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).