Multiparameter study of the physiological reactions of the human organism to complex postural loads

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Abstract

BACKGROUND: Reactions of human cardiovascular system to complex dynamic postural loads were under investigation by previous authors. Individual limiting mode of postural loads, i.e. alternating negative-positive periodic changes of body position angle on tilting table with regard to clinostatic position, was defined. It was demonstrated that application of oscillatory passive dynamic postural loads can cause certain hemodynamic reactions, which expression depend on postural loads dynamic characteristics and subject’s primary state.

AIM: Aim of the study is to develop comprehensive methodology (practice) that explores regulation mechanisms of cardiovascular, respiratory, central and autonomic nervous systems and their reactions to physiological strains with assigned properties (intensity, direction, periodicity and duration of postural loads).

MATERIALS AND METHODS: 30 young healthy participants took part in the study. Physiological indicators were registered in dynamic mode synchronously with trajectory of participant’s motion. This study implemented common statistical methods as much as original means of analysis by integrating theory of dynamic systems.

RESULTS: Evaluation of synchronously registered physiological indicators by means of instrumental and software application, in particular, postural loads protocols of various intensity and motion direction, showed that oscillatory passive dynamic postural mode allows considerable improvements in overall blood circulation and gas exchange in the lungs. These changes constitute in a rise of systemic and local blood flow without significant shift of arterial pressure, increased frequency of heartbeats and respiratory rate.

CONCLUSIONS: Continuous monitoring of participant’s condition during complex postural loads give an opportunity for studying a set of physiological reactions and has a future implication in scientifically approved recommendations that describe practical use of postural loads as a correction technology for human health state and training.

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About the authors

Timofey V. Sergeev

Institute of Experimental Medicine

Email: stim9@yandex.ru
ORCID iD: 0000-0001-9088-0619
SPIN-code: 4952-5143
Scopus Author ID: 57201501819
https://iemspb.ru/department/eco-phys-dep/neuroeco-lab/

Cand. Sci. (Biol.), Head of the Biocontrol Physiology Laboratory at the Ecological Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Elizaveta A. Agapova

Institute of Experimental Medicine

Email: agapova.ea@iemspb.ru
ORCID iD: 0000-0002-0767-2120
SPIN-code: 3383-9600

Researcher Associate of Ecological Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Aleksei A. Anisimov

Institute of Experimental Medicine

Email: g4nslinger@gmail.com
ORCID iD: 0000-0003-1363-1971
Scopus Author ID: 56349671900

Cand. Sci. (Tech.), Researcher Associate of Ecological Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Alexandr V. Belov

Institute of Experimental Medicine

Email: avbelov1@yandex.ru
ORCID iD: 0000-0002-8042-5185
SPIN-code: 2638-4027
Scopus Author ID: 57202357308

Cand. Sci. (Tech.), Leading Researcher of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Nadezhda L. Guseva

Institute of Experimental Medicine

Author for correspondence.
Email: guseva_nad@mail.ru
ORCID iD: 0000-0002-4660-3873
SPIN-code: 3322-0668
Scopus Author ID: 56711691000

Cand. Sci. (Biol.), Leading Researcher of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Mariya V. Kuropatenko

Institute of Experimental Medicine

Email: kuropatenko.mv@iemspb.ru
ORCID iD: 0000-0003-4214-9412
SPIN-code: 5024-3499
Scopus Author ID: 57222538102

MD, Cand. Sci. (Med.), Senior Researcher of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Tatyana V. Novikova

Institute of Experimental Medicine

Email: prianishnikova.tv@iemspb.ru
ORCID iD: 0000-0002-1885-7999
Scopus Author ID: 57236043800

Junior Researcher of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Arlan F. Sagirov

Institute of Experimental Medicine

Email: arlansagirov@gmail.com
ORCID iD: 0000-0003-4924-3487
SPIN-code: 2971-2086

Researcher Assistant of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Nikolay B. Suvorov

Institute of Experimental Medicine

Email: nbsuvorov@yandex.ru
ORCID iD: 0000-0003-2363-6012
SPIN-code: 6164-5994
Scopus Author ID: 16521673300

Dr. Sci. (Biol.), Professor, Leading Researcher of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

Petr I. Tolkachev

LLC “Automated Rehabilitation Systems”

Email: mehanurg@mail.ru
SPIN-code: 2515-0608
Scopus Author ID: 55439861400

Head of the laboratory

Russian Federation, Saint Petersburg

Alexandr V. Shabrov

Institute of Experimental Medicine

Email: ashabrov@gmail.com
SPIN-code: 5316-7290
Scopus Author ID: 7003970182

MD, Dr. Sci. (Med.), Professor, Full Member of RAS, Chief Researcher of Ecologic Physiology Department

Russian Federation, 12, Academician Pavlov Str., Saint Petersburg, 197376

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Supplementary files

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2. Fig. 5. Fragment of an electroencephalogram with a short flash of theta waves in the frontal leads (highlighted by an oval). Кg = 1,48

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3. Fig. 1. Schematic representation of the subject on the tilting table (a), its symbolic graphic designation (b) and the dependence of the tilting table angle inclination on time for the postural loads protocol used (c). Ап — the angle of the tilting table position; t — time

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4. Fig. 2. Research biotechnical system for complex automated postural loads taking into account the subject’s position in space and simultaneous registration and processing of data. PL — postural loads; ECG — electrocardiogram; CRG — cardiorhythmogram; EEG — electroencephalogram; SBP — systolic blood pressure; DBP — diastolic blood pressure; TPVR — total peripheral vascular resistance; SV — shock volume; SI — shock index; BR — breathing rate

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5. Fig. 3. Synchronous registration of physiological signals of subject C: a — electrocardiogram (ECG); b — cardiorhythmogram (CRG); c — systolic blood pressure and diastolic blood pressure (SBP and DBP); d — pulse blood pressure (PBP). HR — heart rate

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6. Fig. 4. Comparative dynamics of changes in mean arterial pressure (a), shock index (b), heart rate (c) during postural loads in the modes: anti-orthostatic position (stroke) and oscillatory passive dynamic postural loads (solid). MAP — mean arterial pressure; SI — shock index; HR — heart rate; OPDP — oscillatory passive dynamic postural (loads); AOP — anti-orthostatic position

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7. Fig. 6. An example of simultaneous recording of the O2 and CO2 concentrations in exhaled air in a continuous mode during of the oscillatory passive dynamic postural loads load and in the horizontal phases Background-1 and Background-2 synchronously with the recording of other physiological parameters

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Copyright (c) 2021 Sergeev T.V., Agapova E.A., Anisimov A.A., Belov A.V., Guseva N.L., Kuropatenko M.V., Novikova T.V., Sagirov A.F., Suvorov N.B., Tolkachev P.I., Shabrov A.V.

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