The molecular mechanisms of drug resistance of glioblastoma. Part 3. Differentiation and apoptosis of glioblastoma cells
- Authors: Chernov A.N.1, Galimova E.S.1,2, Shamova O.V.1,3
-
Affiliations:
- Institute of Experimental Medicine
- Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- Saint Petersburg State University
- Issue: Vol 23, No 2 (2023)
- Pages: 47-62
- Section: Analytical reviews
- Published: 25.08.2023
- URL: https://journals.eco-vector.com/MAJ/article/view/83598
- DOI: https://doi.org/10.17816/MAJ83598
- ID: 83598
Cite item
Abstract
Glioblastomas are one of the most malignant and frequent human tumors, characterized by rapid growth, metastasis, resistance to therapy and the formation of relapses. The formation of multidrug resistance mechanisms in glioblastomas cells is often combined with inhibition of cell death and differentiation pathways and prevents an increase in the effectiveness of therapy in this group of patients. The review examines the relationship of molecular mechanisms of multidrug resistance with differentiation and apoptosis of glioblastomas with an emphasis on identifying new targets among proteins, microRNAs, suppressor genes, and oncogenes.
Full Text
About the authors
Alexander N. Chernov
Institute of Experimental Medicine
Author for correspondence.
Email: al.chernov@mail.ru
ORCID iD: 0000-0003-2464-7370
Scopus Author ID: 26649406700
PhD, Cand. Sci. (Biol.), Senior Research Associate, Department of General Pathology and Pathological Physiology
Russian Federation, Saint PetersburgElvira S. Galimova
Institute of Experimental Medicine; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: elvira8galimova@gmail.com
ORCID iD: 0000-0002-8773-0932
Scopus Author ID: 24331659400
PhD, Cand. Sci. (Biol.), Senior Research Associate of Interdisciplinary Laboratory for Neurobiology; Senior Research Associate, Department of General Pathology and Pathological Physiology
Russian Federation, Saint Petersburg; Saint PetersburgOlga V. Shamova
Institute of Experimental Medicine; Saint Petersburg State University
Email: oshamova@yandex.ru
ORCID iD: 0000-0002-5168-2801
Scopus Author ID: 6603643804
ResearcherId: F-6743-2013
Dr. Sci. (Biol.), Assistant Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of General Pathology and Pathological Physiology; Professor of the Department of Biochemistry
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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