Endogenous digitalis-like substances and alcohol dependence

Abstract


Endogenous digitalis-like substances (EDLS) and Na/K-ATPase are involved into water-salt homeostasis, regulation of cardiovascular system functions and pathogenesis of arterial hypertension. Na/K-ATPase activity is modified also by ethanol. Experiments conducted by authors showed the ability of EDLS, in particular, marinobufagenin, to suppress motivational-and-reinforcing properties of this psychoactive agent. "Na/K-ATPase- EDLS" system is supposed to contribute to individual vulnerability to alcohol dependence, while centrally acting selective inhibitors of Na/K-ATPase are potential medications for the treatment of alcoholism. Data are presented also demonstrating the involvement of EDLS into the pathogenesis of arterial hypertension in alcohol withdrawal and in neurotoxic properties of this agent.

Full Text

Restricted Access

About the authors

V A Kashkin

Valdman Institute of Pharmacology, Pavlov Medical University


E E Zvartau

Valdman Institute of Pharmacology, Pavlov Medical University


A Ya Bagrov

Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg


References

  1. Беспалов А.Ю., Звартау Э.Э. Нейропсихофармакология антагонистов NMDA-рецепторов. СПб.: Невский Диалект, 2000. С. 297.
  2. Крупицкий Е.М., Звартау Э.Э. Применение фармакологических средств для стабилизации ремиссий и профилактики рецидивов при алкоголизме // Ученые записки СПбГМУ им. акад. И. П. Павлова. 2003. Т. X. № 2. С. 12-23.
  3. Altura В.М. and Altura В.Т. Alcoholism. Biomedical and genetic aspects. New York, Oxford: Pergamon Press, 1989. P. 167-215.
  4. Bagrov A.Y., Fedorova O.V., Dmitrieva R.I. et al. Plasma marinobufagenin-like and ouabain-like immunore-activity during saline volume expansion in anesthetized dogs //Cardiovasc. Res. 1996. Vol. 31. P. 296-305.
  5. Bagrov A.Y., Fedorova O.V., Dmitrieva R.I. et al. Bufodienolide nature of endogenous inhibitor of Na/K ATPase in the urine from patients with acute myocardial infarction // Hypertension. 1998. Vol. 31. P. 1097-1103.
  6. Bagrov Y.Y, Dmitrieva N.I., ManusovaN.B. et al. Digitalislike factors and ethanol consumption and reward //2ns European Congress of Pharmacology (Budapest, July 3-7, 1999). / Abstracts. Fundamental and Clinical Pharmacology. 1999a. Vol. 13. Suppl. 1. P. 226.
  7. Bagrov Y.Y, Dmitrieva N.I., ManusovaN.B. et al. Involvement of endogenous digitalis-like factors in voluntary selection of alcohol by rats // Life Sci. 1999b. Vol. 64. P. 219-225.
  8. Bagrov A Y., Bagrov Y.Y, Fedorova O.V et al. Endogenous digitalis-like ligands of the sodium pump: possible involvement in mood control and ethanol addiction // Eur. Neuropshychopharmacol. 2002. Vol. 12. P. 1-12.
  9. Bagrov Y.Y, Manusova N.B., Egorova LA. et al. Endogenous digitalis-like substances and Na/K-ATPase inhibition in diabetes mellitus // Front Biosci. 2005 Vol. 10. P. 2257-2262.
  10. Beauge L. Do Na/K-ATPase isoforms anchor where they must or where they can? // News Physiol. Sci. 1993. Vol. 8. P. 239-240.
  11. Beguin P., Wang X., Firsov D., Puoti et al. The subunit is a specific component of the Na/K-ATPase and modulates its transport function // EMBO. 1997. Vol. 16. P. 4250-4260.
  12. Besirli C.G, Gong TW, Lomax M.I. Novel beta 3 isoform of the Na,K-ATPase beta subunit from mouse retina//Biochim. Biophys. Acta. 1997. Vol.3.№ 1350-1. P. 21-26.
  13. Blanco G., DeTomaso A.W., Koster J. et al. The alphasubunit of the Na,K-ATPase has catalytic activity independent of the beta-subunit // J. Biol. Chem. 1994. Vol. 269. P. 23420-23425.
  14. Blanco G., Koster J.C., Sanchez G., Mercer R.W. Kinetic properties of the alpha 2 beta 1 and alpha 2 beta 2 isozymes of the Na/K-ATPase // Biochemistry. 1995. Vol. 34. P. 319-325.
  15. Blanco G., Mercer R.W. Isozymes of the Na-K- ATPase: heterogeneity in structure, diversity in function // Am. J. Physiol. 1998. Vol. 275. P. 633-650.
  16. Blaustein M.P Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness //Am. J. Physiol. 1993. Vol. 264. P. 1367-1387.
  17. Brines M.L., Robbins R.J. Inhibition of alpha 2/alpha 3 sodium pump isoforms potentiates glutamate neurotoxicity // Brain Res. 1992. Vol. 591. P. 94-102.
  18. Buckalew V.M., Martinez F.J., Green W.E. The effect of dialysates and ultrafiltrates of plasma of saline-loaded dogs on toad bladder sodium transport // J. Clin. Invest. 1970. Vol. 49. P. 926-935.
  19. Cameron R., Klein L., Shyjan A.W.et al. Neurons and astroglia express distinct subsets of Na/K-ATPase alpha and beta subunits // Brain Res. Mol. 1994. Vol. 21. №3-4. P. 333-343.
  20. Chen K.K., Kovarikova A. Pharmacology and toxicology of toad venom // J. Pharm. Sci. 1967. Vol. 56. P. 1535-1541.
  21. Chen Y., Wixom P.M., Sun A.Y Enhanced (Na+K)-ATPase activity and expression in mouse brain after chronic ethanol administration // Neurochem. Res. 1997. Vol. 22. P. 583-588.
  22. Di Gennaro C, Vescovi P.P., Barilli A.L. et al. Sodium sensitivity as a main determinant of blood pressure changes during early withdrawal in heavy alcoholics //Alcohol. Clin. Exp. Res. 2002. Vol. 26. № 12. P. 1810-1815.
  23. De Witte P. The role of neurotransmitters in alcohol dependence: animal research //Alcohol. Alcohol. 1996. Vol.31 (Suppl. 1). P. 13-16.
  24. Dingledine R., McBain C.J. Glutamate and aspartate // Siegel G.J, Agranoff B.W, Albers R.W, Fisher S.K, Uhler M.D. (eds.) / Basic Neurochemistry. Lippincott-Raven Press, Philadelphia, PA. 6th edn. 1999. P. 315-333.
  25. Estevez A.Y, Song D, Phillis J.W, O'Regan M.H. Effects of the anion channel blocker DIDS on ouabain-and high K(+)-induced release of amino acids from the rat cerebral cortex // Brain Res. Bull. 2000. Vol. 52. P. 45-50.
  26. Fedorova O.V., Bagrov A.Y. Inhibition of Na/K ATPase from rat aorta by two Na/K pump inhibitors, ouabain and marinobufagenin: evidence of interaction with different alpha-subunit isoforms // Am. J. Hypertens. 1997. Vol. 10. P. 929-935.
  27. Fedorova O.V, Lakatta E.G., Bagrov A.Y. Differential effects of acute NaCl loading on endogenous ouabain-like and marinobufagenin-like ligands of the sodium pump in Dahl hypertensive rats // Circulation. 2000. Vol. 102. P. 3009-3014.
  28. Fedorova O.V, Kolodkin N.I, Agalakova N.I. et al. Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats // Hypertension. 2001. Vol. 37. P. 462-466.
  29. Ferrandi M, Minotti E, Salardi S. et al. Ouabainlike factor in Milan hypertensive rats // Am. J. Physiol. 1992. Vol. 263. P. 739-748.
  30. Foley T.D, Linnoila M. Nanomolar concentrations of ouabain block ethanol-inducible Na+,K(+)-ATPase activity in brain // Eur. J. Pharmacol. 1995. Vol. 292. P. 287-292.
  31. Foley T.D, Rhoads D.E. Stimulation of synaptosomal Na+,K(+)-ATPase by ethanol: possible involvement of an isozyme-specific inhibitor of Na+,K(+)-ATPase // Brain Res. 1994. Vol. 653. P. 167-172.
  32. Forbush B, Kaplan J.H, Hoffman J.F. Characterization of a new photoaffinity derivative of ouabain: labeling of the large polypeptide and of a proteolipid component of the Na, K-ATPase // Biochemistry. 1978. Vol. 17. P. 3667-3676.
  33. Foster D.M, Huber M.D, Klemm W.R. Ethanol may stimulate or inhibit (Na+/K+)-ATPase, depending upon Na+ and K+ concentrations // Alcohol. 1989. Vol. 6. P. 437-443.
  34. Gonick H.C, Ding Y, Vaziri N.D, и др. Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states // Clin. Exp. Hypertens. 1998. Vol. 20. P. 617-627.
  35. Good PJ, Richter K, Dawid I.B. A nervous system-specific isotype of the beta subunit of Na+,K(+)-ATPase expressed during early development of Xeno-pus laevis // Proc. Natl. Acad. Sci. USA. 1990. Vol. 87. P. 9088-9092.
  36. Gloor S, Antonicek И, Sweadner K.J. et al. The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase // J. Cell. Biol. 1990. Vol. 110. P. 165-174.
  37. Jacobson I, Hagberg H, Sandberg M, Hamberger A. Ouabain-induced changes in extracellular aspartate, glutamate and GABA levels in the rabbit olfactory bulb in vivo // Neurosci. Lett. 1986. Vol. 64. P. 211-215.
  38. Kashkin V.A, Bagrov A.Y, Fedorova O.V. et al. Marinobufagenin suppression of ethanol-seeking behavior is associated with inhibition of the brain cortex Na/K-ATPase in mice // Eur. Neuropshychopharmacology. 2002. Vol. 12. P. 217-223.
  39. Kashkin V.A, Zvartau E.E, Fedorova O.V. et al. Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats // Eur. Neuropsychopharmacol. 2008. Vol. 18. № LP. 74-77.
  40. Klatsky A.L, Friedman G.D. Alcohol and longevity // Am. J. Public Health. 1995. Vol. 85. № 1. P.16-28.
  41. Komiyama Y, Dong X.H, NishimuraN. et al. A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure // Clin. Biochem. 2005. Vol. 38. № LP. 36-45.
  42. Kuzmin A, Semenova S, Zvartau E, and de Vry J. Effects of calcium channel blockade on intravenous selfadministration of ethanol in rats // Eur. Neuropsychopharmacol. 1999. Vol. 9. № 3. P. 197-203.
  43. Levenson R. Isoforms of the Na,K-ATPase: family members in search of function // Rev. Physiol. Biochem. Pharmacol. 1994. Vol. 123. P. 1-45.
  44. Lingrel J.B, Orlowski J, Shull M.M., Price E.M. Molecular genetics of Na,K-ATPase // Prog. Nucleic. Acid. Res. Mol. Biol. 1990. Vol. 38. P. 37-89.
  45. Lingrel J.B. Na,K-ATPase: isoform structure, function, and expression // J. Bioenerg. Biomembr. 1992. Vol. 24. P. 263-270.
  46. Lingrel J.B, Kuntzweiler T. Na+,K(+)-ATPase // J. Biol. Chem. 1994. Vol. 5. № 269-231. P. 19659-19662.
  47. Lopatin D.A, Ailamazian E.K, Dmitrieva R.I. et al. Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia // J. Hypertens. 1999. Vol. 17. P. 1179-1187.
  48. Martin-Vasallo P, Dackowski W, Emanuel J.R, Levenson R. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression // J. Biol. Chem. 1989. Vol. 264. P. 4613^1618.
  49. McDonough A.A, Geering K, Farley R.A. The sodium pump needs its beta subunit // FASEB. 1990. Vol. 4. P. 1598-1605.
  50. Nhamburo P.T., Salafsky B.P, Tabakoff B, Hoffman PL. Effects of ethanol on ouabain inhibition of mouse brain (Na+,K+)ATPase activity // Biochem. Pharmacol. 1987. Vol. 36. P. 2027-2033.
  51. Priyadarshi A, Periyasamy S, Burke T.J. et al. Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat // Kidney Int. 2002. Vol. 61 №2. P. 542-546.
  52. Shull G.E, Greeb J, Lingrel J.B. Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain // Biochemistry. 1986. Vol. 25. P. 8125-8132.
  53. Shull G.E, Schwartz A, Lingrel J.B. Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA // Nature. 1985. Vol. 316. P. 691-695.
  54. Shamraj O.I, Lingrel J.B. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. // Proc. Natl. Acad. Sci. USA. 1994. Vol. 20. № 91-26. P. 12952-12956.
  55. Sverdlov E. D, Monastyrskaya G. S, Broude N. E. et al. The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit // FEBS Lett. 1987. Vol. 217. P. 275-278.
  56. Sweadner K.J. Isozymes of the Na+/K+-ATPase // Biochim. Biophys. Acta. 1989. Vol. 988. P. 185-220.
  57. Weinberger M.H, Miller J.Z, Luft FC. et al. Definitions and characteristics of sodium sensitivity and blood pressure resistance // Hypertension. 1986. Vol. 8. №6. Pt. 2. P. II 127-134.
  58. Weinberger M.H. Salt sensitivity of blood pressure in humans // Hypertension. 1996. Vol. 27. № 3. Pt. 2. P. 481-490.
  59. Westerink B.H, Damsma G, de Vries J.B. Effect of ouabain applied by intrastriatal microdialysis on the in vivo release of dopamine, acetylcholine, and amino acids in the brain of conscious rats // J. Neurochem. 1989. Vol. 52. P. 705-712.

Statistics

Views

Abstract - 98

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2009 Kashkin V.A., Zvartau E.E., Bagrov A.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies