Changes in immunoreactivity of orexin-A-positive neurons after restraint stress and cold stress applications



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Abstract

As it is known influence of any stressor factors leads to considerable changes of immune system activity that affects current of infection process. Change of the expression level of preproorexin gene has been studied after restraint and cold-restraint stress application. Also selective alteration of immunereactivity of orexin-containing neurons is established after these kinds of stress application. Orexin-containing neurons are located mostly in structures on brain slices of 28,29,31 levels, and have different immunoreactivity, that testifies a functional heterogeneity of population of orexin-containing neurons in hypothalamus. The revealed changes of reactions in the central nervous system during stress-induced dysfunction of immune system are important for considering in clinical practice in the people with infection process who have transferred strong psychoemotional stress.

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K Z Shainidze

Research Institute of Experimental Medicine of the RAMS, St. Petersburg

N S Novikova

Research Institute of Experimental Medicine of the RAMS, St. Petersburg

G M Aleshina

Research Institute of Experimental Medicine of the RAMS, St. Petersburg

J A Darinsky

Gertsen State Pedagogical University, St. Petersburg

A P Synchikova

Research Institute of Experimental Medicine of the RAMS, St. Petersburg

E A Korneva

Research Institute of Experimental Medicine of the RAMS, St. Petersburg

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Copyright (c) 2009 Shainidze K.Z., Novikova N.S., Aleshina G.M., Darinsky J.A., Synchikova A.P., Korneva E.A.

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