Breast cancer and pregnancy


Breast cancer during pregnancy is still a relatively uncommon occurrence. It has been shown that breast cancer occurs in between 1/3000 and 1/10,000 of all pregnant women [3-7] Research to date has shown that the relationship between pregnancy and breast cancer is quite complex [40]. However, the available studies are limited by substantial potential biases, and concerns remain for some women and their doctors about the risks of pregnancy after breast cancer. This article reviews what is known about the association between pregnancy and breast cancer, discusses treatment options for women diagnosed with the disease during pregnancy, and summarizes evidence regarding the safety of pregnancy after breast cancer.

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About the authors

V Я Semiglazov

N. N. Petrov Research Institute of Oncology, St. Petersburg, Russia

G A Dashyan

N. N. Petrov Research Institute of Oncology, St. Petersburg, Russia

V V Semiglazov

St Petersburg State I. P. Pavlov Medical University


  1. Семиглазов В.Ф., Семиглазов В.В., Иванов В.Г. и др. Гормонотерапия операбельного рака молочной железы // Мед. акад. журн. 2003. Т. 3. № 3. С. 79-87.
  2. Семиглазов В.Ф., Дашян Г.А., Семиглазов В.В. и др. Применение антиангиогенных препаратов в адь-ювантном лечении рака молочной железы // Мед. акад. журн. 2008. Т. 8. № 2. С. 74-83.
  3. Betson J.R., Golden M.L. Cancer and pregnancy // Am. J. Obstet. Gynecol. 1961. Vol. 81. P. 718-728.
  4. Donegan W.L. Cancer and pregnancy // CA Cancer J. Clin. 1983. Vol. 33. P. 194.
  5. Anderson J.M. Mammary cancers and pregnancy // Br. Med. J. 1979. Vol. 1. P. 1124-1127.
  6. Peete C.H., Honeycutt H.C., Cherny W.B. Cancer of the breast in pregnancy // N С Med. J. 1966. Vol. 27. P. 514-520.
  7. White T.T. Carcinoma of the breast and pregnancy // Ann. Surg. 1954. Vol. 139. P. 9-18.
  8. Haagensen CD., Stout A.P. Carcinoma of the breast: Criteria of operability //Ann. Surg. 1943. Vol. 118. P. 859-870.
  9. Cheek J.H. Survey of current opinions concerning carcinoma of the breast in association with pregnancy // Arch. Surg. 1953. Vol. 66. P. 664-672.
  10. Nugent P., O'Connell T.X. Breast cancer in pregnancy //Arch. Surg. 1985. Vol. 120. P. 1221-1224.
  11. Petrek J.A. Pregnancy-associated breast cancer // Semin. Surg. Oncol. 1991. Vol. 7. P. 306-310.
  12. King R.M., Welch J.S., Martin J.L. et al. Carcinoma of the breast associated with pregnancy // Surg. Gynecol. Obstet. 1985. Vol. 160. P. 228-232.
  13. Ribeiro G., Palmer M.K. Breast carcinoma associated with pregnancy: A clinician's dilemma // Br. Med. J. 1977. Vol. 2. P. 1524-1527.
  14. Demarsky L.J., Neishtadt E.L. Breast cancer and pregnancy // Breast. 1980. Vol. 7. P. 17-21.
  15. Harris J.R., Morrow M., Bonadona G. Cancer of the breast / in De Vita V.T., Hellman S., Rosenberg S.A. (eds.). // Cancer: Principles and Practice of Oncology. 4 ed. Philadelphia, JB Lippincott, 1993.
  16. Applewhite R.R., Smith L.R., DeVicenti F. Carcinoma of the breast associated with pregnancy and lactation // Am. Surg. 1973. Vol. 39. P. 101-104.
  17. Clark R.M., Reid J. Carcinoma of the breast in pregnancy and lactation // Int. J. Radiat. Oncol. Biol. Phys. 1978. Vol. 4. P. 693-698.
  18. Crosby C.H., Barclay Т.Н.С Carcinoma of the breast: Surgical management of patients with special conditions // Cancer. 1971. Vol. 28. P. 1628-1636.
  19. Petrek J.A., Dukoff R., Rogatko A. Prognosis of pregnancy-associated breast cancer // Cancer. 1991. Vol. 67. P. 869-872.
  20. Ribeiro G., Jones D.A., Jones M. Carcinoma of the breast associated with pregnancy // Br. J. Surg. 1986. Vol. 73. P. 607-609.
  21. Canter J.W., Oliver G.C, Zaloudek C.J. Surgical diseases of the breast during pregnancy // Clin. Obstet. Gynecol. 1983. Vol. 26. P. 853-864.
  22. Cheek J.H. Cancer of the breast in pregnancy and lactation //Am. J. Surg. 1973. Vol. 126. P. 729-731.
  23. Holleb A.I., Farrow J.H. The relation of carcinoma of the breast and pregnancy in 283 patients // Surg. Gynecol. Obstet. 1962. Vol. 115. P. 65-71.
  24. Hoover H.C Carcinoma of the breast in pregnancy and lactation / in Bland K.I. (ed.). // The Breast: Comprehensive Management of Benign and Malignant Diseases. Philadelphia, WB Saunders, 1991.
  25. Peters M.V The effect of pregnancy in breast cancer / in Forrest A.P.M., Kunkler P.B. (eds.). // Prognostic Factors in Breast Cancer. Baltimore, Williams and Wilkins, 1968.
  26. Novotny D.B., Maygarden S.J., Shermer R.W. et al. Fine needle aspiration of benign and malignant breast masses associated with pregnancy //Acta Cytol. 1991. Vol. 35 (6). P. 676-686.
  27. Max M.H., Klamer T.W. Pregnancy and breast cancer // South. Med. J. 1983. Vol. 76. P. 1088-1090.
  28. Byrd B.F., Bayer D.S., Robertson J.C et al. Treatment of breast tumors associated with pregnancy and lactation//Ann. Surg. 1962. Vol. 155 (6). P. 940.
  29. Petrek J.A. Breast cancer during pregnancy // Cancer. 1993. Vol. 74. P. 518-527.
  30. Miller R., Mulvihill S. Small head size after atomic radiation//Teratology. 1976. Vol. 14. P. 355-357.
  31. Shapira D.V., Chudley A.E. Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy // Cancer. 1984. Vol. 54. P. 800-803.
  32. Sweet D.L., Kinzie J. Consequences of radiotherapy and antineoplastic therapy for the fetus // J. Reprod. Med. 1976. Vol. 17. P. 241-246.
  33. Zemlickis D., Lishner M., Degendorfer P. et al. Fetal outcome after in utero exposure to cancer chemotherapy //Arch. Intern. Med. 1992. Vol. 152. P. 573-576.
  34. Cooper D.R., Butterfield J. Pregnancy subsequent to mastectomy for cancer of the breast // Ann. Surg. 1970. Vol. 171. P. 429-433.
  35. White T.T. White WC. Breast cancer and pregnancy, a report of 49 cases followed 5 years //Arm. Surg. 1956. Vol. 144. P. 384-393.
  36. DiFronzo L.A., O'Connell T.X. Breast cancer in pregnancy and lactation // Surg. Clin. N. Am. 1996. Vol. 76 (2). P. 267-278.
  37. Donegan WL. Pregnancy and breast cancer // Obstet. Gynecol. 1977. Vol. 50. P. 244-251.
  38. Mignot L., Morvan F., Berdah J. Pregnancy after breast cancer: Results of a case-control study // Presse Med. 1986. Vol. 15. P. 1961-1964.
  39. Clark R.M., Chua T. Breast cancer and pregnancy: the ultimate challenge // Clin. Oncol. 1989. Vol. 1. P. 11-18.
  40. Surbone A. The complex relationship between pregnancy and breast cancer // Expert Opin. Pharmacother. 2002. Vol.3. P. 429-431.
  41. Woo J.C., Yu Т., Hurd T.C. Breast cancer in pregnancy: A literature review //Arch. Surg. 2003. Vol. 138. P. 91-99 (incl. discussion).
  42. Leon DA., Carpenter L.M., Breeders MJ. et al. Breast cancer in Swedish women before age 50: Evidence of a dual effect of completed pregnancy // Cancer Causes Control. 1995. Vol. 6. P. 283-291.
  43. Albrektsen G., Heuch I., Kvale G. The short-term and long-term effect of a pregnancy on breast cancer risk: A prospective study of 802,457 parous Norwegian women // Br. J. Cancer. 1995. Vol. 72. P. 480-484.
  44. Lambe M., Hsieh C, Trichopoulos D. et al. Transient increase in the risk of breast cancer after giving birth //N. Engl. J. Med. 1994. Vol. 331. P. 5-9.
  45. Gentilini O., Cremonesi M., Trifiro G. et al. Safety of sentinel node biopsy in pregnant patients with breast cancer//Ann. Oncol. 2004. Vol. 15. P. 1348-1351.
  46. Nettleton J., Long J., Kuban D. et al. Breast cancer during pregnancy: Quantifying the risk of treatment delay // Obstet. Gynecol. 1996. Vol. 87. P. 414-418.
  47. Williams S.F., Schilsky R.L. Antineoplastic drugs administered during pregnancy // Semin. Oncol. 2000. Vol. 27. P. 618-622.
  48. Partridge A.H., Garber J.E. Long-term outcomes of children exposed to antineoplastic agents in utero // Semin. Oncol. 2000. Vol. 27. P. 712-726.
  49. Berry D.L., Theriault R.L., Holmes F.A. et al. Management of breast cancer during pregnancy using a standardized protocol // J. Clin. Oncol. 1999. Vol. 17. P. 855-861.
  50. Giacalone PL., Laffargue F., Benos P. Chemotherapy for breast carcinoma during pregnancy: A French national survey // Cancer. 1999. Vol. 86. P. 2266-2272.
  51. Mignot L., Morvan F., Berdah J. et al. Pregnancy after treated breast cancer. Results of a case-control study // Presse Med. 1986. Vol. 15. P. 1961-1964.
  52. Sankila R., Heinavaara S., Hakulinen T. Survival of breast cancer patients after subsequent term pregnancy: "Healthy mother effect" //Am. J. Obstet. Gynecol. 1994. Vol. 170. P. 818-823.
  53. Kroman N., Jensen M.B., Melbye M. et al. Should women be advised against pregnancy after breast-cancer treatment? // Lancet. 1997. Vol. 350. P. 319-322.
  54. Velentgas P., Daling J.R., Malone K.E. et al. Pregnancy after breast carcinoma: outcomes and influence on mortality // Cancer. 1999. Vol. 85. P. 2424-2432.
  55. Gelber S., Coates A.S., Goldhirsch A. et al. Effect of pregnancy on overall survival after the diagnosis of early-stage breast cancer // J. Clin. Oncol. 2001. Vol. 19. P. 1671-1675.
  56. Mueller B.A., Simon M.S., Deapen D. et al. Childbear-ing and survival after breast carcinoma in young women//Cancer. 2003. Vol. 98. P. 1131-1140.
  57. Blakely L.J., Buzdar A.U., Lozada J.A. et al. Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence // Cancer. 2004. Vol. 100. P. 465-469.



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Copyright (c) 2009 Semiglazov V.Я., Dashyan G.A., Semiglazov V.V.

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