The role of platelet activation in the pathogenesis of retinal venous thrombosis



Cite item

Full Text

Abstract

In the present study, the role of different platelet glycoprotein receptors Gpla, Gplb and Gpllla gene polymorphisms in the intravascular activation of platelets was studied in 182 patients with retinal venous occlusion. It was concluded that the 434(C/T) Gplba and 1565(T/C) Gpllla polymorphisms were associated with the increased platelet aggregation and represent the risk factors of the ischemic form of retinal venous thrombosis.

Full Text

Restricted Access

About the authors

S N Tultseva

I.P. Pavlov State Medical University

References

  1. Белязо О.Е. Клиническая значимость исследования тромбоцитарного звена гемостаза у больных с артериальными и венозными тромбозами // Ученые записки. 2004. Т. XI (3). С. 68-73.
  2. Воронина Е.Н., Филиппенко М.Л., Сергеевичев Д.С. и др. Мембранные рецепторы тромбоцитов: функции и полиморфизм // Вестник ВОГиС. 2006. Т. 10(3). С. 553-564.
  3. Головина О.Г. Роль фактора Виллебранда в реакциях гемостаза и тромбоза // Ученые записки. 2004. Т. XI (3). С. 37-44.
  4. Капустин С.И., Шмелева В.М., Паншина A.M. и др. Генетическая предрасположенность к венозному тромбозу: роль полиморфизмов компонентов плазменного и тромбоцитарного звеньев гемостаза// Ученые записки. 2004. Т. XI (3). С. 10-15.
  5. Кацнельсон Л.А., Форофонова Т.И., Бунин А.Я. Сосудистые заболевания глаза. М., 1990. 272 с.
  6. Паншина A.M. Роль некоторых тромбоцитарных рецепторов в развитии тромбофилии // Ученые записки. 2004. Т. XI (3). С. 31-37.
  7. Шишкова А.С. Тромбоцитопатии, врожденные и приобретенные. СПб., 2008. 383 с.
  8. Croft S.A., Hampton К.К., Sorrell J.A. et al. The Gpla C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction // British J. Haematol. 1999. Vol. 106. P. 771-776.
  9. Dodson P.M., Haynes J., Starezynski J. et al. The platelet glycoprotein la/Па gen polymorphism С807Т/ G873A: a novel risk factor for retinal vein occlusion // Eye. 2003. Vol. 17 (6). P. 772-777.
  10. Dodson P.M., Westwick J., Marcs G. et al. Betathromboglobulin and platelet factor 4 levels in retinal vein occlusion // Br. J. Ophthalmol. 1983. Vol. 67. P. 143-146.
  11. Feng D., Lindpaintner K., Larson M.G. et al. Increased platelet aggregability associated with platelet Gpllla P1A2 polymorphism: the Framingham Offspring Study //Arterioscler. Thromb. Vase. Biol. 1999. Vol. 19. P. 1142-1147.
  12. Gadelha Т., Biancardi A.L., Forster M. et al. 807С/ T polymorphism in platelet glycoprotein la gene is not associated with retinal vein occlusion // Graefes. Arch. Clin. Exp. Ophthalmol. 2007. Vol. 245 (11). P. 1739-1740.
  13. Glueck C.J., Wang P., Bell H. et al. Associations of thrombophilia, hypofibrinolysis, and retinal vein occlusion // Clin. Appl. Thromb. Hemost. 2005. Vol. 11 (4). P. 375-378.
  14. Hansen L., Kristensen H.L., Век T. et al. Markers of thrombophilia in retinal vein thrombosis // Acta Ophthalmol. Scand. 2000. Vol. 78. P. 523-526.
  15. Houtsmuller A.J., Vermeulen J.A.C.M., Klompe M. et al. The influence of ticlopidine on the natural course of retinal vein occlusion //Agents Action Suppl. 1984. Vol. 15. P. 219-229.
  16. Kritzik M., Savage В., Nugent D.J. et al. Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet al-pha2 betal density // Blood. 1998. Vol. 92. P. 23822388.
  17. Kunicki T.J., Orchekowski R., Annis D. et al. Variabil-iti of integrin alpha2 betal activiti on human platelets // Blood. 1993. Vol. 82. P. 2693-2703.
  18. Kunicki T.J., Kritzik M., Annis D.S. et al. Hereditary variation in platelet integrin alpha2 betal densiti is associated with two silent polymorphisms in the alpha2 gene coding sequence // Blood. 1997. Vol. 89. P. 1939- 1943.
  19. Lane D.A., Grant P.J. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease //Blood. 2000. Vol. 95. P. 1517-1532.
  20. Larsson J., Hillarp A. The prothrombin gene G2021 OA mutation and the platelet glycoprotein Ilia polymorphism P1A2 in patients with central retinal vein occlusion // Thromb. Res. 1999. Vol. 96. P. 323-327.
  21. Lefkovits J., Plow E.F., Topol E.J. Platelet glycoprotein IPo/IIIa receptors in cardiovascular medicine // N. Engl. J. Med. 1995. Vol. 332. P 1553-1559.
  22. Marian A.J., Brugada R., Kleiman N.S. Platelet glycoprotein Ilia P1A polymorphism and myocardial infarction //N. Engl. J. Med. 1996. Vol. 335. P. 1071.
  23. Meyr D., Girma J.P. von Willebrand factor: structure and function // Thromb. Haemost. 1993. Vol. 70 (1). P. 99-104.
  24. Mikkelsson J., Perola M., Penttila A. et al. The GpIIa (beta3 integrin) P1A polymorphism in the early development of coronary atherosclerosis // Atherosclerosis. 2001. Vol. 154 (3). P. 721-727.
  25. Moroi M., Jung S.M., YoshidaN. Genetic polymorphism of platelet glycoprotein lb // Blood. 1984. Vol. 64. P. 622-629.
  26. Moshfegh K., Wuillemin W.A., Redondo M. et al. Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study // Lancet. 1999. Vol. 353. P. 351-354.
  27. Park S.C., Park H.Y., Park C. et al. Association of the gene polymorphisms of platelet glycoprotein la and Ilb/IIIa with myocardial infarction and extent of coronary artery disease in Korean population // Yonsei. Medical. J. 2004. Vol. 45 (3). P. 428-134.
  28. Priluc I.A. Impending central retinal vein occlusion associated with increased platelet aggregabiliti // Ann. Ophthalmol. 1979. Vol. 11. P. 79-84.
  29. Ridker P.M., Hennekens C.H., Schmitz C. et al. Р1А1/ A2 polymorphism of platelet glycoprotein and risks of myocardial infarction, stroke and venous thrombosis // Lancet. 1997. Vol. 349. P. 385-388.
  30. Salomon O., Moisseiev J., Rosenberg N. et al. Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion // Blood coagul. Fibrinolysis. 1998. Vol. 9. P. 617-622.
  31. Salvarani C, Casali В., Fametti E. et al. P1A1/A2 polymorphism of the platelet glycoprotein receptor Ilia and risk of cranial ischemic complications in giant cell arteritis // Arthritis & Rheumatism. Vol. 56 (10). P. 3502-3508.
  32. Santoso S., Kunicki T.J., Kroll H. et al. Association of the platelet glycoprotein la C807T gene polymorphism with nonfatal myocardial infarction in younger patients //Blood. 1999. Vol. 93. P. 2449-2453.
  33. Solomon 0., Moisseiev J., Vilganski T. et al. Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion // Blood Coagul. Fibrinolysis. 2006. Vol. 17 (6). P. 485-488.
  34. Vine A.K. Hyperhomocysteinemia: a new risk factor for central retinal vein occlusion // Trans. Am. Ophthalmol. Soc. 2000. Vol. 98. P. 493-503.
  35. Walsh P.N., Goldberg R.E., Tax R.L. et al. Platelet coagulant activities and retinal vein thrombosis // Thromb. Haemost. 1977. Vol. 38. P. 399-406.
  36. Watson P.G., Gordon J.L., Kok D. et al. Platelet aggregation studies in ischaemic retinal vascular disease // Tranc. Ophthalmol. Soc. UK. 1971. Vol. 91. P. 223-230.
  37. Weger M., Renner W., Steinbrugger I. et al. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion // Ophthalmology. 2005. Vol. 112(11). P. 1910-1915.
  38. Wu Y.Z. Changes in plasma TxB2 and 6-keto-PGFl alpha in patients with retinal vein occlusion // Zhonghua Yan Ke Za Zhi. 1993. Vol. 29. P. 359-361.
  39. Yamamoto Т., Motohiro K., YokoiN. etal. Comparative effect of antiplatelet therapy in retinal vein occlusion evaluated by the particle-counting method using light scattering //Am. J. Ophthalmol. 2004. Vol. 138 (5). P. 809-817.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Tultseva S.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies