Innovation technology in diagnostics and therapy of tuberculosis

The opportunity of use microchip for fast and specific diagnostics of multidrug resistant of M. tuberculosis to isoniazid (in genes katG, inhA, ahpC), to rifampicin (a gene rpoB) is studied. It is carried out research of hereditary predisposition to a tuberculosis of lungs on the basis of molecular HLA typing genes of II class of the main complex histocompatibility loci HLA-DQB1*and HLA-DRB1*.The possibilities to use in the surgery ofTB and non-specific spondylitis the new carbon-carbon implants which prepared with nano-technologies, were examined in experimental and clinical studies. The new implants has a high stiffness, they can protect the spine from deterioration of kyphosis after surgery, they stimulate the bio-implants' adaptation in combine anterior fusion and they can used as a container for antibiotics with their long-time therapeutic concentration in plastic zone without complications and side effects. The combination of the given innovative approaches allows to identify simultaneously the mutations responsible for sensitivity of the activator of a tuberculosis to the basic antitubercular preparations, to generate at an early stage of group with the raised risk of a failure of tubercular defeat and purposefully to spend the strengthened, individualized therapy.

tuberculosis, diagnostics, microchip, resistency, HLA-typing, hereditary predisposition, carbon nano-material, tuberculosis spondylitis, spinal osteomielitis, anterior fusion, implants