The fundamental importance of new biomarkers of brain ischemia


During the analysis of results of research of various biomarkers at 50 patients with stroke, at 40 patients with brain ischemia owing to an atherosclerosis carotid arteries, at 30 patients with epilepsy syndromes, at 20 children born by mothers-addicts, the conclusion about the big clinical importance of such biomarkers, as PARK7 and nucleoside diphosphate kinase A, S-100b, Acetylpolyamine oxidase [AcPAO], S-jet fiber, GluRI an AMPA-receptor, autoantibodies (aAbs) to opiate and glutamate to receptors (type AMPA and glutamate to receptors NMDA, NmDa- autoantibodies, NR1, NR-2A-NR2D and NR3A) which help early diagnostics of pathological process, its degree of expressiveness and dynamics under the influence of therapeutic actions is made. Wide introduction in clinical practice of biomarkers is recommended: NR1, NR-2A-NR2D and NR3A, GluRI an AMPA-receptor. Literary data about genetic and biochemical markers is cited at degenerate diseases of nervous system, at Alzheimer's and Parkinson's diseases.

Full Text

Restricted Access

About the authors

A A Skoromets

I.P. Pavlov State Medical University, St. Petersburg

S A Dambinova

I.P. Pavlov State Medical University, St. Petersburg

O K Granstrem

I.P. Pavlov State Medical University, St. Petersburg

A P Skoromets

I.P. Pavlov State Medical University, St. Petersburg

T A Skoromets

I.P. Pavlov State Medical University, St. Petersburg

D G Smolko

I.P. Pavlov State Medical University, St. Petersburg

M V Shumilina

I.P. Pavlov State Medical University, St. Petersburg

G A Hunteev

I.P. Pavlov State Medical University, St. Petersburg


  1. Гусев Е.И., Скворцова В.И. Ишемия головного мозга. М.: Медицина, 2001. 327 с.
  2. Дамбинова С.А., Скоромец А.А., Громова Л.Г., Илюхина А.Ю. Уровень аутоантител к фрагменту глутаматного рецептора NMDA-типа у больных с острым нарушением мозгового кровообращения // Нейрохимия. 1998. Т. 14. Вып. 4. С. 420422.
  3. Илюхина А.Ю. Динамика накопления аутоантител к глутаматным рецепторам NMDA-типа в крови больных в остром периоде церебрального инсульта: Автореф. дис.. канд. мед. наук. СПб., 1998. 23 с.
  4. Скоромец А.А., Дамбинова С.А., Илюхина А.Ю., Сорокоумов В.А. Аутоантитела к глутаматным рецепторам NMDA-типа в крови пациентов с острым ишемическим и геморрагическим инсультом // Журн. неврол. и психиатрии им. С. С. Корсакова. 1997. Т. 97. № 6. С. 53-58.
  5. Скоромец А.П. Инфекционные поражения нервной системы у новорожденных: Автореф. дис.. д-ра мед. наук. СПб., 2001. 70 с.
  6. Скоромец ТА. Вторичная ишемия головного мозга в остром периоде черепно-мозговой травмы: Автореф. дис.. д-ра мед. наук. СПб., 2002. 42 с.
  7. Allard L., Burkhard P.R., Lescuyer P. et al. PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke // Clin. Chem. 2005. Vol. 51. P. 2043-2051.
  8. Albers G.W., Caplan L.R., Easton J.D. et al. Transient ischemic attack - proposal for a new definition // N. Engl. J. Med. 2002. Vol. 347 (21). P. 1713-1716.
  9. Bokesch P.M., Izykenova G.A., Justice J.В., Easley K.A., Dambinova S.A. NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients // Stroke. 2006. Vol. 37. P. 14321436.
  10. Brightwell R.E., Sherwood R.A., Athanasiou Т., Hamady M., Cheshire N.J.W. The neurological morbidity of carotid revascularisation: using markers of cellular brain injury to compare CEA and CAS // Eur. J. Vase. Endovasc. Surg. 2007. Vol. 34. P. 552-560.
  11. Dambinova S.A., Izykenova G., Gappoeva M., Wang Y., Hoffer B. NMDA receptors expression and immunoreactivity in experimental cerebral ischemia and hemorrhage // J. Neurochem. 2003. Vol. 87. P. 144.
  12. Gingrich M.D., Traynelis S.F. Serine proteases and brain damage - is there a link? // Trends Neurosci. 2000. Vol. 23. P. 399-407.
  13. Dambinova S.A., Kbounteev G.A., Izykenova G.A. et al. Blood test detecting autoantibodies to N-methyl-d-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke // Clin. Chem. 2003. Vol. 49. P. 1752-1762.
  14. Dambinova S.A., Khounteev G.A., Skoromets A.A. Multiple panel of markers for TIA/stroke evaluation [Letter] // Stroke. 2002. Vol. 33. P. 1181-1182.
  15. Dambinova S.A. Brain Biomarkers for Cerebral Ischemia: NMDA Receptor Degradation and Blood Assay Development // AACC Press. Forthcoming.
  16. Dambinova S.A., Brightwell R.E., Khunteev G.A., Cheshire N.J. NR2 peptide correlates with acute cerebrovascular events after carotid revascularization // Submitted to Stroke.
  17. Dambinova S.A, Khunteev G.A., Olson D.A. et al. NR2 peptide indicates transient ischemic attack and acute ischemic stroke // Int. J. Stroke. 2008. Vol. 3. P. 153-154. Abstract POO 1-246.
  18. Hideyuki Tomitori, Teruyoshi Usui, Naokatsu Saeki et al. Polyamine Oxidase and Acrolein as Novel Biochemical Markers for Diagnosis of Cerebral Stroke // Stroke. 2005. Vol. 36. P. 2609.
  19. Hill M.D., Yiannakoulias N., Jeerakathil T. et al. The high risk of stroke immediately after transient ischemic attack: a population based study // Neurology. 2004. Vol. 62. P. 2015-2020.
  20. Glynn Т., Tews M., Izykenova G. et al. The clinical utility of serum NR2 peptide assay in the diagnosis of patients presenting to the emergency department with acute cerebrovascular ischemic events // Ann. Emerg. Med. 2007. Vol. 50. P. 35. Abstract 107.
  21. Gorelick PB. Lipoprotein-associated phospholipase A2 and risk of stroke //Am. J. Cardiol. 2008. Vol. 101 (12A). P.34F-40F.
  22. Mackay J., Mensah G. The Atlas of Heart Disease and Stroke // World Health Organization. 2004. P. 50-51.
  23. Mario Di Napoli, Francesca Papa Vittorio Bocola. C-Reactive Protein in Ischemic Stroke An Independent Prognostic Factor // Stroke. 2001. Vol. 32. P. 917.
  24. Pilar Delgado, Jose Alvarez Sabin et al. Plasma SI00B Level After Acute Spontaneous Intracerebral Hemorrhage // Stroke. 2006. Vol. 37. P. 2837.
  25. Sharp CD., Fowler M., Jackson Т.Н. et al. Human neuroepithelial cells express NMDA receptors // BMC Neurosci. 2003. Vol. 4. P. 28.
  26. Weissman J.D., Khunteev G.A., Olson D., Izykenova G., Dambinova S. NR2 peptide levels correlate with acute cortical stroke volume and may detect reversible ischemia// Stroke. 2007. Vol. 38. P. 494. Abstract P39.
  27. Whiteley W., Tseng M.C., Sandercock P. Blood biomarkers in the diagnosis of ischemic stroke. A systematic review // Stroke. 2008. Vol. 39. P. 2902-2909.



Abstract - 93


Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Copyright (c) 2009 Skoromets A.A., Dambinova S.A., Granstrem O.K., Skoromets A.P., Skoromets T.A., Smolko D.G., Shumilina M.V., Hunteev G.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies