STRESSORS IN EARLY POSTNATAL PERIOD ABOLISH DEVELOPMENT OF ALCOHOL PREFERENCE IN ADULT FEMALE RATS (POTENTIAL ROLE OF к-OPIOID RECEPTORS)

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Abstract


It is known that stress facilitates desire for alcohol consumption and formation of alcohol dependence in adolescents. Data from the literature suggest that this influence is associated with plastic changes in the dyn-orphin - к-opioid receptors system in the brain. The aim of this study was to compare effects of stressors and к-opioid receptor stimulation during early postnatal development on formation of alcohol dependence in adolescent rats. Male and female rats were subjected to stressors, stimulation of к-opioid receptors or both factors simultaneously. Upon reaching the age of 70-90 days, which corresponds to the adolescent period of human life, the rats were alcoholized. Regardless of the age of exposure, the stressor abolished formation of alcohol preferences in female adolescent rats. A similar result of stimulation of kappa-opioid receptors suggests that they are involved in the observed effect.

V N Mukhin

Institute of Experimental Medicine

A P Kozlov

Institute of Experimental Medicine

I N Abdurasulova

Institute of Experimental Medicine

K I Pavlov

Institute of Experimental Medicine

V V Sizov

Institute of Experimental Medicine

A V Matsulevitch

Institute of Experimental Medicine

V M Klimenko

Institute of Experimental Medicine

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Copyright (c) 2017 Mukhin V.N., Kozlov A.P., Abdurasulova I.N., Pavlov K.I., Sizov V.V., Matsulevitch A.V., Klimenko V.M.

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