STRESSORS IN EARLY POSTNATAL PERIOD ABOLISH DEVELOPMENT OF ALCOHOL PREFERENCE IN ADULT FEMALE RATS (POTENTIAL ROLE OF к-OPIOID RECEPTORS)



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

It is known that stress facilitates desire for alcohol consumption and formation of alcohol dependence in adolescents. Data from the literature suggest that this influence is associated with plastic changes in the dyn-orphin - к-opioid receptors system in the brain. The aim of this study was to compare effects of stressors and к-opioid receptor stimulation during early postnatal development on formation of alcohol dependence in adolescent rats. Male and female rats were subjected to stressors, stimulation of к-opioid receptors or both factors simultaneously. Upon reaching the age of 70-90 days, which corresponds to the adolescent period of human life, the rats were alcoholized. Regardless of the age of exposure, the stressor abolished formation of alcohol preferences in female adolescent rats. A similar result of stimulation of kappa-opioid receptors suggests that they are involved in the observed effect.

Full Text

Restricted Access

About the authors

V N Mukhin

Institute of Experimental Medicine

A P Kozlov

Institute of Experimental Medicine

I N Abdurasulova

Institute of Experimental Medicine

K I Pavlov

Institute of Experimental Medicine

V V Sizov

Institute of Experimental Medicine

A V Matsulevitch

Institute of Experimental Medicine

V M Klimenko

Institute of Experimental Medicine

References

  1. Hildebrandt T., Greif R. Stress and addiction // Psychoneuroendocrinology. 2013. Vol. 38, No 9. P. 1923-1927.
  2. Азарных Т.Д. Посттравматические стрессы и употребление алкоголя в юношеском возрасте // Академический журнал Западной Сибири. 2013. Т. 9, № 2 (45). С. 20. [Azarnykh T. D. Post-traumatic stress and alcohol use in adolescence // Akademicheskij zhurnal Zapadnoj Sibiri. 2013. Vol. 9, No 2 (45). P. 20.]
  3. Anda R.F., Whitfield C.L., Felitti V.J., Chapman D., Edwards V.J., Dube S.R., Williamson D.F. Adverse Childhood Experiences, Alcoholic Parents, and Later Risk of Alcoholism and Depression // Psychiatric Services. 2002. Vol. 53, No 8. P. 1001-1009.
  4. De Bellis M.D. Developmental traumatology: a contributory mechanism for alcohol and substance use disorders // Psychoneuroendocrinology. 2002. Vol. 27, No 1-2. P. 155-170.
  5. Enoch M.-A. The role of early life stress as a predictor for alcohol and drug dependence // Psychopharmacology (Berl.). 2011. Vol. 214, No 1. P. 17-31.
  6. Graham Y.P., Heim C., Goodman S.H., Miller A.H., Nemeroff C.B. The effects of neonatal stress on brain development: implications for psychopathology // Development and Psychopathology. 1999. Vol. 11, No 3. P. 545-565.
  7. Маслова Л.Н., Булыгина В.В., Амстиславская Т.Г. Длительная социальная изоляция и социальная нестабильность в подростковом возрасте у крыс: непосредственные и отдаленные физиологические и поведенческие эффекты // Журнал высшей нервной деятельности им. И.П. Павлова. 2009. Т. 59, № 5. С. 598-609 [Maslova L.N., Bulygina V.V., Amstislavskaya T.G. Social Isolation and Social Instability in Adolescence in Rats: Immediate and Long-term Physiological and Behavioral Effects // Zh Vyssh Nerv Deiat I.P. Pavlova. 2009. Vol. 59, No 5. P. 598-609.]
  8. Dallman M.F. Early Life Stress: Nature and Nurture // Endocrinology. 2014. Vol. 155, No 5. P. 1569-1572.
  9. Fernández M.S., Fabio M.C., Miranda-Morales R.S., Virgolini M.B., De Giovanni L.N., Hansen C., Wille-Bille A., Nizhnikov M.E., Spear L.P., Pautassi R.M. Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response // Alcohol. 2016. Vol. 51. P. 89-100.
  10. Fone K.C.F., Porkess M.V. Behavioural and neurochemical effects of post-weaning social isolation in rodents - Relevance to developmental neuropsychiatric disorders // Neuroscience & Biobehavioral Reviews. 2008. Vol. 32, No 6. P. 1087-1102.
  11. Holgate J.Y., Bartlett S.E. Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders // Brain Sciences. 2015. Vol. 5, No 3. P. 258-274.
  12. Meaney M.J., Brake W., Gratton A. Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse? // Psychoneuroendocrinology. 2002. Vol. 27, No 1-2. P. 127-138.
  13. Weaver I.C.G. Shaping adult phenotypes through early life environments // Birth Defects Research Part C: Embryo Today: Reviews. 2009. Vol. 87, No 4. P. 314-326.
  14. Беренштейн Ю.А. Субъективные причины употребления алкоголя руководителями // Здоровье - основа человеческого потенциала: проблемы и пути их решения. 2014. Т. 9, № 2. С. 574-576. [Berenshtejn Ju.A. Subjective causes of alcohol use by managers // Zdorov'e - osnova chelovecheskogo potenciala: problemy i puti ih reshenija. 2014. Vol. 9, No 2. P. 574-576]
  15. Gustafsson L., Oreland S., Hoffmann P., Nylander I. The impact of postnatal environment on opioid peptides in young and adult male Wistar rats // Neuropeptides. 2008. Vol. 42, No 2. P. 177-191.
  16. Ploj K., Roman E., Nylander I. Long-term effects of short and long periods of maternal separation on brain opioid peptide levels in male Wistar rats // Neuropeptides. 2003. Vol. 37, No 3. P. 149-156.
  17. Ploj K., Roman E., Nylander I. Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male wistar rats // Neuroscience. 2003. Vol. 121, No 3. P. 787-799.
  18. Flaisher-Grinberg S., Persaud S.D., Loh H.H., Wei L.-N. Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc // PNAS. 2012. Vol. 109, No 23. P. 9167-9172.
  19. Karkhanis A.N., Rose J.H., Weiner J.L., Jones S.R. Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System // Neuropsychopharmacology. 2016. Vol. 41, No 9. P. 2263-2274.
  20. Lindholm S., Werme M., Brené S., Franck J. The selective κ-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat // Behavioural Brain Research. 2001. Vol. 120, No 2. P. 137-146.
  21. Anderson R.I., Becker H.C. Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol // Alcohol Clin. Exp. Res. 2017. Online.
  22. Walker B.M., Valdez G.R., McLaughlin J.P., Bakalkin G. Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence // Alcohol. 2012. Vol. 46, No 4. P. 359-370.
  23. Sirohi S., Walker B.M. Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system // Front. Mol. Neurosci. 2012. Vol. 5. P. 95.
  24. McLaughlin J.P., Land B.B., Li S., Pintar J.E., Chavkin C. Prior Activation of Kappa Opioid Receptors by U50,488 Mimics Repeated Forced Swim Stress to Potentiate Cocaine Place Preference Conditioning // Neuropsychopharmacology. 2006. Vol. 31, No 4. P. 787-794.
  25. Butte J.C., Kakihana R., Farnham M.L., Noble E.P. The Relationship Between Brain and Plasma Corticosterone Stress Response in Developing Rats // Endocrinology. 1973. Vol. 92, No 6. P. 1775-1779.
  26. Sapolsky R.M., Meaney M.J. Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period // Brain Research Reviews. 1986. Vol. 11, No 1. P. 65-76.
  27. Schapiro S. Pituitary ACTH and compensatory adrenal hypertrophy in stress-non-responsive infant rats // Endocrinology. 1962. Vol. 71. P. 986-989.
  28. Barr G.A., Wang S., Carden S. Aversive properties of the κ-opioid agonist U50,488 in the week-old rat pup // Psychopharmacology. 1994. Vol. 113, No 3-4. P. 422-428.
  29. Carden S.E., Barr G.A., Hofer M.A. Differential effects of specific opioid receptor agonists on rat pup isolation calls // Developmental Brain Research. 1991. Vol. 62, No 1. P. 17-22.
  30. Kehoe P., Boylan C.B. Behavioral effects of kappa-opioid-receptor stimulation on neonatal rats // Behavioral neuroscience. 1994. Vol. 108, No 2. P. 418-423.
  31. Nizhnikov M.E., Pautassi R.M., Varlinskaya E., Rahmani P., Spear N.E. Ontogenetic Differences in Ethanol’s Motivational Properties during Infancy // Alcohol. 2012. Vol. 46, No 3. P. 225-234.
  32. Wiedenmayer C.P. Plasticity of defensive behavior and fear in early development // Neuroscience and biobehavioral reviews. 2009. Vol. 33, No 3. P. 432-441.
  33. Махинько В.И., Никитин В.Н. Константы роста и функциональные периоды развития в постнатальной жизни белых крыс // Молекулярные и физиологические механизмы возрастного развития. Киев: Наукова думка, 1975. С. 308-326. [Mahin'ko V.I., Nikitin V.N. Growth constants and functional developmental periods in postnatal life of white rats // Molecular and physiological mechanisms of age-related development. Kiev: Naukova dumka, 1975. P. 308-326.]
  34. Ošt’ádalová I., Babický A. Periodization of the early postnatal development in the rat with particular attention to the weaning period // Physiol Res. 2012. Vol. 61, Suppl. 1. P. S1-7.
  35. Anderson R.I., Agoglia A.E., Morales M., Varlinskaya E.I., Spear L.P. Stress, kappa manipulations, and aversive effects of ethanol in adolescent and adult male rats // Neuroscience. 2013. Vol. 249. P. 214-222.
  36. Takahashi L.K. Ontogeny of behavioral inhibition induced by unfamiliar adult male conspecifics in preweanling rats // Physiology & Behavior. 1992. Vol. 52, No 3. P. 493-498.
  37. Wadenberg M.-L.G. A Review of the Properties of Spiradoline: A Potent and Selective k-Opioid Receptor Agonist // CNS Drug Reviews. 2003. Vol. 9, No 2. P. 187-198.
  38. Аназарова С.А., Иванов В.В., Изверова А.А., Кадура А.А. Алкогольная интоксикация у детей и подростков // Бюллетень медицинских интернет-конференций. 2013. Т. 3, № 11. С. 1209. [Anazarova S.A., Ivanov V.V., Izverova A.A., Kadura A.A. Alcohol intoxication in children and adolescents // Bjulleten' medicinskih internet-konferencij. 2013. Vol. 3, No 11. P. 1209.]
  39. Huot R.L., Thrivikraman K., Meaney M.J., Plotsky P.M. Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment // Psychopharmacology. 2001. Vol. 158, No 4. P. 366-373.
  40. Jaworski J.N., Francis D.D., Brommer C.L., Morgan E.T., Kuhar M.J. Effects of early maternal separation on ethanol intake, GABA receptors and metabolizing enzymes in adult rats // Psychopharmacology. 2005. Vol. 181, No 1. P. 8-15.
  41. Gustafsson L., Ploj K., Nylander I. Effects of maternal separation on voluntary ethanol intake and brain peptide systems in female Wistar rats // Pharmacology Biochemistry and Behavior. 2005. Vol. 81, № 3. P. 506-516.
  42. Roman E., Ploj K., Nylander I. Maternal separation has no effect on voluntary ethanol intake in female Wistar rats // Alcohol. 2004. Vol. 33, No 1. P. 31-39.
  43. Teicher M.H., Andersen S.L., Polcari A., Anderson C.M., Navalta C.P. Developmental neurobiology of childhood stress and trauma // Psychiatr. Clin. North Am. 2002. Vol. 25, No 2. P. 397-426, vii-viii.
  44. Morales M., Anderson R.I., Spear L.P., Varlinskaya E.I. Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: Impact of age and sex // Dev Psychobiol. 2014. Vol. 56, No 4. P. 700-712.
  45. Chartoff E.H., Mavrikaki M. Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction // Front. Neurosci. 2015. Vol. 9.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Mukhin V.N., Kozlov A.P., Abdurasulova I.N., Pavlov K.I., Sizov V.V., Matsulevitch A.V., Klimenko V.M.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies