Vol 17, No 3 (2017)

Articles
ELECTROPHYSOLOGICAL EVALUATION OF MECHANISMS OF MILITARY-PROFESSIONAL ADAPTATION
Pavlov K.I., Mukhin V.N., Syrtsev A.V., Archimuk A.N., Sysoev V.N., Petrenko M.I.

Abstract

The aim of our work is theoretical substantiation of application of electroencephalographic method (EEG) in the evaluation of cognitive functions as indirect indicators of the adaptive homeostatic subsystem status and functional reserves of the individual. The review includes the application of EEG in the professional psychological selection, screening of the functional status and the study of cognitive functions among servicemen and specialists of the law enforcement agencies. We write about physiological mechanisms of functional status and cognitive functions in the norm, stress, pathology. We analyze studies of fractal, stochastic parameters of EEG. We propose to include EEG into cross-validation studies that will be included into the modern methodical apparatus of psychodiagnostics.
Medical academic journal. 2017;17(3):7-19
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PATIENTS WITH NEUROCYRKULTING ASTHENIA: PECULIARITIES OF PSYCHOEMOTICAL STATE AND HEALTH STATUS
Frolova N.L., Streltsov D.N., Sergeev T.V., Solntsev V.N., Kameneva E.G., Sofronov G.A.

Abstract

Aim of the work: study of peculiarities of psychoe motional state and health status of people suffering from neurocirculatory asthenia, determination of their most informative indices as well as of the contribution of psychical and physical components to their health. Materials and methods: 74 persons suffering from neurocirculatory asthenia took part in the research voluntarily. Indices of «life quality» were researched by using the Russian version of SF-36 health status survey; the evaluation of reactive and personal state anxiety was carried out by using the Spielberger$Hanina survey, the level of depression was determined according to the Tsung scale. All research results were analyzed by using methods of simple and multidimensional statistics. Results: the most informative indices of psychoe motional state and health status of persons suffering from neurocirculatory asthenia are Social Functioning, state anxiety, Role-Emotional, amount of physical pain, Role-Physical, and Vitality. Social Functioning of persons suffering from neurocirculatory asthenia have fundamental importance in perception by ill people of their state of health and are connected with all informative indices of psychoe motional state and life quality. Opinion: the contribution Physical and Mental Health of persons suffering from neurocirculatory asthenia has been determined.
Medical academic journal. 2017;17(3):20-26
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THE ROLE OF CHLAMYDIA PNEUMONIAE AND INTERLEUKIN-8 IN DESTABILIZATION OF ATHEROSCLEROTIC PLAQUE IN HUMAN
Pigarevsky P.V., Maltseva S.V., Snegova V.A., Davydova N.G., Yakovleva O.G., Vorozhbit R.A.

Abstract

Research objective: The aim of this work was a comparative study of the contents of the Chlamydia pneumoniae and IL-8 in unstable and stable atherosclerotic lesions in humans,and an assessment of their role in the destabilization of atherosclerotic plaques. Materials and methods: Investigated 38 aortic tissue samples received from 63±7 years men who died from coronary heart disease. Verification of unstable progressive atherosclerotic plaques was conducted using histological staining Oil Red O and hematoxylin Mayer. Chlamydia pneumoniae to identify modified histological method Romanowski-Giemsa. Determination of IL-8 was made highly sensitive two-stage biotin-streptavidin method. Analysis of the results was carried out using a light microscope Leica DM 2500 and computer program «Leica Application Suite Version 3.4.0». Results: In surface divisions of unstable atherosclerotic lesions of human arterial walls identified Chlamydia pneumoniae, expressed cellular products of IL-8 and mononuclear cells infiltrates consisting of lymphocytes and macrophages. Conclusion: The results can indicate a combined mutually enhances action Chlamydia pneumoniae and IL-8 in the formation of unstable atherosclerotic lesions.
Medical academic journal. 2017;17(3):27-31
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GFAP-IMMUNOPOSITIVE CELLS AMONG EPENDYMOCYTES OF THE THIRD VENTRICLE OF THE RAT BRAIN
Kirik O.V., Sufieva D.A.

Abstract

The aim of the article. The article is devoted to distribution of intermediate filament protein GFAP in ependymocytes lining the third ventricle of rat brain. Materials and Methods. The study was performed on adult male Wistar rats (n=20) , GFAP immunopositive cells were detected by immunocytoche mical reaction. Results. The study demonstrated that in rat brain GFAP is one of cytoskeleton components of the majority of ependymal cells of the third ventricle adjacent to the habenula nuclei and paraventricular nucleus of the thalamus. Conclusion. It was shown that differentiated neurons with set of markers which are not characteristic for mature neurons are present in this region. Thus, the habenula area along with ependymal layer covering it are a special zone that can be considered as possible reserve proliferative zone of the diencephalon.
Medical academic journal. 2017;17(3):32-37
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EFFECT OF COURSE APPLICATION OF ENTEROCOCCUS FAECIUM L-3 ON PSYCHOEMOTINAL STATE OF PATIENTS WITH MULTIPLE SCLEROSIS
Matsulevich A.V., Abdurasulova I.N., Tarasova E.A., Ermolenko E.I., Bisaga C.N., Alekhina C.C., Skulyabin D.I., Suvorov A.N., Klimenko V.M.

Abstract

The research objective is comparison of psychoe motional state of patients suffering from disseminated sclerosis that were taking Enterococcus faecium L-3 and patients and that were not taking it. Research materials and methods. For evaluation of psychoe motional state of patients suffering from disse minated sclerosis two groups were created (control group and experimental group), each of the m amounted to 15 persons having definite diagnosis dissminated sclerosis. Standard questionnaires were used («Dominant condition» and «Actual condition» by L.V. Kulikov, questionnaire «Health,activ-ity,mood»,scale of situational (reactive) state anxiety by Ch.D. Spilberger and Yu.L. Khanin,and technique of differential diagnostics of depressive states by V. Zung). Results. After a course of probiotics intake indices at patients of experimental group (р<0.05) have been definitely improved in accordance withscales of the «Dominating state» questionnaire: «Relaxedness - potential stress» , «Evenness - psychic tension» , «Stability - instability of emotional background», «Satisfaction - dissatisfaction withlife in general» and in accordance withthe scale „Evenness - psychictension“ of the „Actual state“ questionnaire. Opinion. Obtained results bear evidence that the course intake of Enterococcus faecium L-3 has positive influence on psychoe motional state of patients having the diagnosis disse minated sclerosis.
Medical academic journal. 2017;17(3):38-46
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IN VIVO PRODUCTION OF INSULIN-LIKE GROWTH FACTOR CODED BY PLASMID DNA
Dukhovlinov I.V., Bogomolova E.G., Dobrovolskaya O.V., Fedorova E.A., Klaus A.M., Ishuk C.A., Klimov N.A., Simbirtsev A.S.

Abstract

The aim was to explore the expression of recombinant insulin-like growth factor (IGF-1) after intramuscular electroporation of mice with plasmid DNA coding this protein. For this purpose synthetic gene coding IGF-1 was introduced into plasmid pcDNA3, giving pcDNA3igf-1 and Escherichia coli strain E.coli DH10 (pcDNA3igf-1) , the producer of this plasmid , was created. Highly purified plasmid pcDNA3igf-1 was used for intramuscular electroporation with the aid of the electric device designed at the laboratory to generate electric pulses. IGF-1 concentrations in sera were determined by ELISA. Testing several modes of electric pulses had shown that the most effective mode for IGF-1 expression in Balb/c mice in vivo was single pulse of square profile with the amplitude of 160 V and 2 0 milliseconds duration. After intramuscular injection of 5 0 micrograms of pcDNA3igf-1, followed by immediate electric pulse the maximal concentration of IGF-1 in serum increased to 324 ng/ml exceeding the control level 3,44 times and high level of IGF-1 was observed during 7 days after electroporation.
Medical academic journal. 2017;17(3):47-52
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MORPHOFUNCTIONAL CHARACTERISTICS OF ENDOMETRIUM IN WOMEN WITH DISORDERS IN THE REPRODUCTIVE SYSTEM
Morotskaya A.V.

Abstract

Objective. Conducting systematic analysis of data on morphofunctional characteristics of the endometrium during the "window of implantation' : in normal and pathological conditions. Materials and methods. The analysis of 59 sources of literature in the electronic databases such as "PubMed", "eLIBRARY", "Doctor's Library' : was performed. Results. Problems of infertility and miscarriage do not lose their relevance and require new solutions. The morphofunctional state of the endometrium is important in the implantation process. Complex of structural and functional characteristics of the endometrium ensuring successful implantation is defined as endometrial receptivity. Endometrial receptivity is generally considered on three levels: genetic, proteomic and histological. In the process of implantation , various molecules are involved, providing a multifactorial "dialogue" : between the endometrium and the blastocyst. Such molecules include cytokines, adhesins, antiadhesins, growth factors, ion channels. The full binding of sex steroids with their receptors in the endometrium leads to its adequate phase transformation. Conclusion. The review presents current knowledge about the importance of molecular factors in the receptivity of the endometrium during implantation.
Medical academic journal. 2017;17(3):53-61
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STRESSORS IN EARLY POSTNATAL PERIOD ABOLISH DEVELOPMENT OF ALCOHOL PREFERENCE IN ADULT FEMALE RATS (POTENTIAL ROLE OF к-OPIOID RECEPTORS)
Mukhin V.N., Kozlov A.P., Abdurasulova I.N., Pavlov K.I., Sizov V.V., Matsulevitch A.V., Klimenko V.M.

Abstract

It is known that stress facilitates desire for alcohol consumption and formation of alcohol dependence in adolescents. Data from the literature suggest that this influence is associated with plastic changes in the dyn-orphin - к-opioid receptors system in the brain. The aim of this study was to compare effects of stressors and к-opioid receptor stimulation during early postnatal development on formation of alcohol dependence in adolescent rats. Male and female rats were subjected to stressors, stimulation of к-opioid receptors or both factors simultaneously. Upon reaching the age of 70-90 days, which corresponds to the adolescent period of human life, the rats were alcoholized. Regardless of the age of exposure, the stressor abolished formation of alcohol preferences in female adolescent rats. A similar result of stimulation of kappa-opioid receptors suggests that they are involved in the observed effect.
Medical academic journal. 2017;17(3):62-67
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NON-INFECTIOUS PATHOLOGY IN CHILDREN OF FEMALE WORKERS OF NUCLEAR INDUSTRY ENTERPRISE
Sosnina S.F., Okatenko P.V.

Abstract

Aim of the study: Comparative analysis of the structure of non-infectious pathology in descendants of Mayak female workers which had accumulated preconceptional external gamma exposure. Material and methods: A retrospective study was carried out on the basis of the children register of Ozersk city. The structure of somatic pathology of 650 children under 15 years old, 130 of which were children of Mayak female workers was analyzed. Nonparametric statistics methods were applied. Results: The range of external gamma-irradiation doses on the ovaries in mothers of the main group was 0.09-3523.7 mGy; the average absorbed dose on the ovaries was 423.2 mGy. The predominance of respiratory diseases,skin and subcutaneous tissue diseases with a high percentage of allergodermathoses, diseases of digestive syste m with frequent occurrence of gastroduodenal pathology and diseases of hepatobiliary syste m were noted in the structure of the somatic pathology in descendants of irradiated mothers. A high frequency of polymorbidities in the study group was noted. Significant differences with the control were not found. Conclusion: Expansion of children cohort and gathering of new data will allow drawing final conclusions about the contribution of parental exposure to the development of multifactorial diseases in offspring.
Medical academic journal. 2017;17(3):68-76
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K 70-LETIYu AKADEMIKA RAN ALEKSEYa GEORGIEVIChA BAINDURAShVILI
- -.

Abstract

Medical academic journal. 2017;17(3):77-78
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K 60-LETIYu AKADEMIKA RAN, PROFESSORA SERGEYa FEDOROVIChA BAGNENKO
- -.

Abstract

Medical academic journal. 2017;17(3):79-80
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