SYSTEM OF RELATIONSHIP OF THYROID STATUS, ENDOTHELIAL FUNCTION AND NEUROVEGETATIVE REGULATION OF HEART RHYTHM AT PATIENTS SUFFERING WITH ARTERIAL HYPERTENSION



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Abstract

Disrupting the synthesis of thyroid hormones (TG) and endothelial dysfunction (ED) have a significant impact on neurovegetative regulation of heart rhythm and hemodynamic at patients suffering with arterial hypertension (AH), a major risk factor for cardiovascular diseases. Objective: to study the features of influence of TG, the metabolites of nitric oxide (NO) on the indices of heart rate variability and their relationship at healthy individuals and patients suffering with AH. Materials and methods. 185 indigenous people in the highlands of Elbrus region (2200 - 3100 m. above sea level) were surveyed: 115 patients suffering with arterial hypertension of different degrees and 70 healthy persons. All examined patients underwent clinical, instrumental and biochemical examinations, including conducting and evaluating heart rate variability (HRV), determination of thyroid hormones, thyroid stimulating hormone, and stable metabolites of nitric oxide in blood components. Results. The obtained results were systematized by means of factor analysis and multiple regression equations. Dependences of absolute and relative values of indicators and indices of HRV on the concentration of TG and NO metabolites in the blood were obtained. The analysis of the most significant factor signs has allowed to show that metabolism TG and NO is closely connected with the adaptation capabilities of the organism both at healthy persons and at hypertensive patients living in the highlands. Conclusion. The obtained data truly indicate the higher stress of regulatory systems of cardiac rhythm and hemodynamic in hypertensive patients with reduced TG synthesis and decrease in NO concentration in blood.

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About the authors

M H Kurdanova

Institute of biomedical problems of the Russian Academy of Sciences

I A Beslaneev

Institute of biomedical problems of the Russian Academy of Sciences

Md H Kurdanova

Institute of biomedical problems of the Russian Academy of Sciences

L M Batyrbekova

Institute of biomedical problems of the Russian Academy of Sciences

H A Kurdanov

Institute of biomedical problems of the Russian Academy of Sciences

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Copyright (c) 2017 Kurdanova M.H., Beslaneev I.A., Kurdanova M.H., Batyrbekova L.M., Kurdanov H.A.

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