CURRENT CONCEPTS ABOUT TRIGGERS OF INFLAMMATORY REACTIONS IN ATHEROSCLEROSIS (A META-ANALYSIS OF PUBLISHED DATA)



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Abstract

Objective: Examination of the current concept of development of inflammatory reactions in atherosclerosis as presented in the available literature. Materials and methods: Dedicated query tools were used to search for publications addressing the problem of atherogenesis from the modern standpoints. The publications found were subjected to content analysis and reviewed in the historical and analytical perspectives. Results: the primary triggers of the development of atherosclerosis are believed to be the responses of inborn and adaptive immunity to the antigenic activity of oxidized low density lipoproteins and related species, cell death, heat shock proteins, infectious agents, chronic autoimmune diseases in anamnesis, inflammation of the adventitia, hemorrhages in vascular intima, and decreased antiatherogenic antibodies production. Atherosclerosis may be caused by genetically determined inflammatory reactions. Conclusion: Numerous data suggest that chronic inflammatory reactions are at the base of the development of atherosclerosis.

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About the authors

D S Shcheglov

City Mariinsky hospital

Email: shcheglovalar@mail.ru

M V Avdeeva

St. Petersburg State Pediatric Medical University

Email: Lensk69@mail.ru

L V Shcheglova

City Mariinsky hospital; St. Petersburg State Pediatric Medical University

Email: shcheglovalar@mail.ru

I P Dudanov

City Mariinsky hospital

Corresponding member of the Russian Academy of Science

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