CYSTIC HYGROMA OF THE FETUSES NECK: ULTRASOUND FEATURES, PREGNANCY OUTCOMES, MANAGEMENT OF PREGNANT WOMEN

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Abstract


There has been performed the research of ultrasonic characteristics of cystic hygroma of the neck (CHN) of the fetus, whose goal was the improvement of ultrasound diagnosis of this disease in the early stages of pregnancy to improve perinatal outcomes. It analyzed the data of 355 cases of heavy tires. It was found that the frequency of prenatal detection of fetal cystic hygroma of the neck in Diagnostic Center (Medical Genetics) is 2,2 per 1000 fetus, significantly above the prevailing rate of detection of any other fetal abnormalities. The volume fraction of CHN in the structure of congenital malformations is more than 62,8%. Cystic hygroma is detected at a younger age of pregnant women less than 29 years, most often between the ages of 16-24 years. Normal fetal karyotype CHN has been installed in 38,5% of cases, of which 51,7% of the patients are born healthy. Regardless of the term to identify cystic hygroma of the neck of the fetus antero-posterior dimension to 4 mm is a favorable prognostic sign of pregnancy outcome. It is proposed a complex algorithm of comprehensive diagnosis of the condition of the fetus in the visualization of heavy tires in all stages of pregnancy based on these results in order to increase the efficiency of prenatal detection of congenital and hereditary diseases to the regional centers of prenatal diagnosis.

T N Trofimova

Institute of a brain of the person of N. P. Bekhterevoy of the Russian Academy of Sciences; Institute of experimental medicine

Email: Trofimova-TN@avaclinic.ru

D V Voronin

Diagnostic Center (Medical Genetics)

Email: mgc@mail.ru. voronindspb@mail.ru

I V Chubkin

Diagnostic Center (Medical Genetics)

Email: ultrasound@list.ru

E V Petrova

Diagnostic Center (Medical Genetics)

Email: petrova_ev@list.ru

  1. Барсегян А. А., Куприянов М. С., Степаненко В. В., Холод И. И. Методы и модели анализа данных: OLAP и Data Mining.- СПб.: БХВ-Петербург, 2004.- 336 с.
  2. Медведев М. В. Сверим наши часы. II. Протокол второго скринингового ультразвукового исследования в 18-21 неделю беременности // Пренатальная диагностика.- 2014.- Т. 13, № 1.- С. 15-23.
  3. Петрова Е. В., Воронин Д. В., Чубкин И. В. Результаты кариотипирования и исходы беременности при выявлении кистозной гигромы шеи у плода // Лучевая диагностика и терапия.- 2015.- № 4 (6).- С. 54-60.
  4. Comstock C. H., Malone F. D., Ball R. H. et al. Is there a nuchal translucency millimeter measurement above which there is no added benefit from first trimester serum screening? // Am. J. Obstet. Gynecol.- 2006.- Vol. 195.- P. 843.
  5. Nyberg D. A., Filly R. A. Predicting pregnancy failure in ‘empty’ gestational sacs // Ultrasound Obstet. Gynecol.- 2003.- Vol. 21 (1).- P. 9-12.
  6. Zhang X., Gu Y., Lu L. et al. Clinicopathologic features of fetal nuchal cystic hygroma: report of 40 cases // Zhonghua Bing Li Xue Za Zhi.- 2014.- Vol. 43 (3).- P. 173-176.
  7. Chervenak F. A., Isaacson G., Blakemore K. J. et al. Fetal cystic hygroma. Cause and natural history // N. Engl. J. Med.- 1983.- Vol. 309.- P. 822-825.
  8. Chervenak F. A., Isaacson G., Tortora M. A sonographic study of fetal cystic hygromas // J. Clin. Ultrasound.- 1985.- Vol. 13.- Р. 311.
  9. Ромеро Р., Пилу Д., Дженти Ф. и др. Пренатальная диагностика врожденных пороков развития плода / пер. с англ.- М.: Медицина, 1994.- С. 119.
  10. Kitazawa S., Mori K., Kondo T., Kitazawa R. Fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21: a case report // Cases J.- 2009.- Vol. 2.- P. 8280.
  11. Von Kaisenberg C. S., Brand-Saberi B., Christ B. et al. Collagen type VI gene expression in the skin of trisomy 21 fetuses // Obstet. Gynecol.- 1998.- Vol. 91.- P. 319-323.
  12. Lajeunesse C., Stadler A., Trombert B. et al. First-trimester cystic hygroma: prenatal diagnosis and fetal outcome // J. Gynecol. Obstet. Biol. Reprod. (Paris).- 2014.- Vol. 43 (6).- P. 455-462.
  13. Mendilcioglu I., Sanhal C. Y., Yakut S. et al. Prenatal management, pregnancy and pediatric outcome in fetuses with septated cystic hygroma // Ultrasound in Obstetrics & Gynecology.- 2012.- Vol. 40 (Suppl. 1).- P. 171-210.
  14. Wapner R. J., Martin C. L., Levy B. et al. Chromosomal microarray versus karyotyping for prenatal diagnosis // N. Engl. J. Med.- 2012.- Vol. 367.- P. 2175-2184.
  15. Manoharan M., Akinfenwa O. Cystic hygroma: prenatal diagnosis and outcome // Ultrasound Obstet. Gynecol.- 2009.- Vol. 34 (Suppl. 1).- P. 177-284.
  16. Brunn J., Block U., Ruf G. et al. Volumetric analysis of thyroid lobes by real-time ultrasound // Dtsch. Med. Wschr.- 1981.- Vol. 106 (41).- P. 1338-1340.
  17. StatSoft. Inc. (2001). Электронный учебник по статистике.- М.: StatSoft.WEB, 2011: http://www. StatSoft.ru/home/textbook/default.htm.
  18. Haak M. C., Van Vugt J. M. Pathophysiology of increased nuchal translucency: a review of the literature // Hum. Reprod. Update.- 2003.- Vol. 9.- P. 175-184.
  19. Gedikbasi A., Oztarhan K., Aslan G. et al. Multidisciplinary approach in cystic hygroma: prenatal diagnosis, outcome, and postnatal follow up // Pediatr. Int.- 2009.- Vol. 51 (5).- P. 670-677.
  20. Malone F. D., DAlton M. E. First-trimester sonographic screening for Down syndrome // Obstet. Gynecol.- 2003.- Vol. 102.- P. 10661079.
  21. Graesslin O., Derniaux E., Alanio E. et al. Characteristics and outcome of fetal cystic hygroma diagnosed in the first trimester // Acta Obstet. Gynecol. Scand.- 2007.- Vol. 86 (12).- P. 442-446.
  22. Eckmann-Scholz C., Salmassi A., Jonat W., Alkatout I. Distended jugular lymphatic sacs in fetuses with increased nuchal translucency: correlation with first-trimester findings in aberrant karyotypes // J. Matern. Fetal Neonatal Med.- 2014.- Vol. 27 (3).- P. 257-260.
  23. Ganapathy R., Guven M., Sethna F. Natural history and outcome of prenatally diagnosed cystic hygroma // Prent. Diagn.- 2004.- Vol. 24 (12).- P. 965.
  24. Souka A. P., Von Kaisenberg C. S., Hyett J. A. et al. Increased nuchal translucency with normal karyotype // Am. J. Obstet. Gynecol.- 2005.- Vol. 192.- P. 1005.

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Copyright (c) 2016 Trofimova T.N., Voronin D.V., Chubkin I.V., Petrova E.V.

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