ENVIRONMENT-DEPENDENT HUMAN DISEASES: THE EPIGENETIC MECHANISMS OF THEIR DEVELOPMENT AND INHERITANCE

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Abstract


The review presents a critical assessment of recent data about links between ecotoxicology and epigenetics. The major epigenetic changes occurring in embryogenesis and gametogenesis are described as they are influenced by ecotoxicants, primarily bisphenol A (BPA), including its effects on development and differentiation as well as on cognition and behavior. Data about the intergenerational transfer of epigenetic and epigenomic disorders induced by different toxicants during spermatogenesis and early embryogenesis are discussed. Outlined are possible directions of further studies of the role and possible mechanisms of the influences of ecotoxicants on epigenetic disturbances, including DNA methylation and histone acetylation, and of the intergenerational transfer of susceptibility to diseases.

E L Patkin

Institute of Experimental Medicine

Email: lp44@mail.ru
St. Petersburg, Russia

G A Sofronov

Institute of Experimental Medicine

St. Petersburg, Russia Academic RAS

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