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Recent literature raises questions about the role of intestinal microbiota in the regulation of immune functions and in supporting of chronic inflammation upon numerous neurological conditions including multiple sclerosis (MS). On the other hand, almost 70% of MS patients have gastrointestinal problems. Study objective: Analysis of the qualitative and quantitative composition of intestinal microflora in MS patients. Materials and methods: The study group included 21 patients (14 females and 7 males). Intestinal microbiota was studied using bacteriological techniques and real-time polymerase chain reaction (RT PCR). Results: All patients were found to have alterations (dysbiosis) in the compositions of intestinal microbial populations manifested as decreases in symbiotic bacteria and the appearance and excessive proliferation of conditionally pathogenic microorganisms, there being certain intersex differences between patients: women showed decreased proportions of hormone-dependent lactobacilli and the excessive proliferation of weakly pathogenic atypical Escherichia, Citrobacter and Acinetobacter species, whereas men showed high rates of detection of S. aureus, Klebsiella sp., Proteus sp., and Candida fungi. The role of intestinal dysbiosis in the pathogenesis of MS and the possibility to treat disturbances in bacterial homeostasis with probiotics are discussed.

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About the authors

I N Abdurasulova

Institute of Experimental Medicine, St. Petersburg State Pediatric Medical University

St. Petersburg, Russia

E A Tarasova

Institute of Experimental Medicine, Research laboratory «Explana»

St. Petersburg, Russia

E I Ermolenko

Institute of Experimental Medicine, St. Petersburg State University

St. Petersburg, Russia

A V Eliseev

Research laboratory «Explana»

St. Petersburg, Russia

A V Matsulevich

Institute of Experimental Medicine

St. Petersburg, Russia

G N Bisaga

Kirov Military Medical Academy

St. Petersburg, Russia

D I Skulyabin

Institute of Experimental Medicine

St. Petersburg, Russia

A N Suvorov

Institute of Experimental Medicine, St. Petersburg State University

St. Petersburg, Russia

V M Klimenko

Institute of Experimental Medicine

St. Petersburg, Russia


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Copyright (c) 2015 Abdurasulova I.N., Tarasova E.A., Ermolenko E.I., Eliseev A.V., Matsulevich A.V., Bisaga G.N., Skulyabin D.I., Suvorov A.N., Klimenko V.M.

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