IDENTIFIKATsIYa I FUNKTsIONAL'NYY ANALIZ NOVOY MUTATsII V GENE FAKTORA TRANSKRIPTsII KLF11, VYZYVAYuShchEY DIABET MODY

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Abstract



T S Krasnova

Email: tkrasnova24@mail.ru

A S Orekhova

N A Zubkova

A N Tyul'pakov

P M Rubtsov

  1. Bell J., Wainscoat J. Maturity onset diabetes of the young is not linked to the insulin gene // Br. Med. J.- 1983.- Vol. 286, № February.- P. 590-592.
  2. Perakakis N., Danassi D., Alt M. et al. Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box // Mol. Cell. Endocrinol.- 2012.- Vol. 363, №№ 1-2.- P. 20-26.
  3. Neve B., Fernandez-Zapico M., Ashkenazi-Katalan V. et al. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function // Proc. Natl Acad. Sci. USA.- 2005.- Vol. 102, № 13.- P. 4807-4812.
  4. Lomberk G., Grzenda A., Mathison A. et al. Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young // J. Biol. Chem.- 2013.- Vol. 288, № 24.- P. 17745-17758.

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Copyright (c) 2016 Krasnova T.S., Orekhova A.S., Zubkova N.A., Tyul'pakov A.N., Rubtsov P.M.

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