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This research investigates particularities of myocardial fibrogenesis following experimental adrenergic and cholinergic stress. The experiment used 2 series of Wistar rats (20 rats in a serie). 2 hours and 1 month after injection of medicament extracellular space density, collagen density; FGF-2, TGF-β1 cellular and endothelial expression was studied in right and left ventricle’s myocardium. Myocardial collagen density was significantly elevated both 2 hours and 1 month compared to intact animals following acute stress (both adrenergic and cholinergic variant). FGF-2 cellular expression was approximately the same 2 hours and 1 month following both stress variants. TGF-β1 cellular expression was significantly higher following cholinergic stress, than TGF-β1 expression following adrenergic stress (both 2 hours and 1 month after). Therefore, this findings may indicate that myocardial fibrogenesis following cholinergic stress proceeds more actively during first hours and persists 1 month after acute cholinergic stress (supported by prolonged TGF-β cellular expression). In our opinion, acute stress activates profibrotic process, wich, once initiated, could become self-supporting.

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About the authors

V R Veber

Yaroslav-the-Wise Novgorod State University

Email: viktor.veber@novsu.ru
Novgorod, Russia

M P Rubanova

Yaroslav-the-Wise Novgorod State University

Email: kafpdo@mail.ru
Novgorod, Russia

S V Zhmailova

Yaroslav-the-Wise Novgorod State University

Email: zhmailova.svetlana@yandex.ru
Novgorod, Russia

P M Gubskaya

Yaroslav-the-Wise Novgorod State University

Email: kafpdo@mail.ru
Novgorod, Russia

V E Karev

FSBEI SRI of Childhood infections of FMBA of Russia

Email: vadimkarev@yandex.ru
St.-Petersburg, Russia

Y Y Rumyantsev

Yaroslav-the-Wise Novgorod State University

Email: gogathejedi@gmail.com
Novgorod, Russia

N A Kulik

Yaroslav-the-Wise Novgorod State University

Email: nadinechist@mail.ru
Novgorod, Russia

D R Sulimanova

Yaroslav-the-Wise Novgorod State University

Email: kafpdo@mail.ru
Novgorod, Russia


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Copyright (c) 2014 Veber V.R., Rubanova M.P., Zhmailova S.V., Gubskaya P.M., Karev V.E., Rumyantsev Y.Y., Kulik N.A., Sulimanova D.R.

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