Vol 14, No 1 (2014)

Articles
CLINICAL EFFICACY OF RHEOLYTIC THROMBECTOMY IN PATIENTS WITH ACUTE ARTERIAL OCCLUSIONS
Dudanov I.P., Zelenin V.V., Cheremisin V.M.

Abstract

Purpose: This study was designed to evaluate efficacy of Angiojet rheolytic thrombectomy in patients with acute arterial occlusions. Methods: In the group of patients with endovascular correction of acute peripheral arterial occlusion included 33 patients who rheolytic therapy was performed of 54 peripheral arteries. Results: By using AngioJet system for recanalization of acute peripheral arterial occlusion primary technical success was achieved in 57,6 % of patients (19/33); secondary technical success was obtained in 18,2 % of patients (6/33). Criteria of primary technical success was complete relief of pain and increase in pain-free walking distance of more than 500 meters. Secondary technical success was relief of pain and increase in pain-free walking distance of less than 500 meters.
Medical academic journal. 2014;14(1):7-14
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NONINVASIVE ASSESMENT OF LIVER FIBROSIS, SEROLOGICAL MARKERS
Fedorov P.N., Belyakov N.A.

Abstract

There is an increased interest in determining liver fibrosis using biological markers in recent years. Serological markers of liver fibrosis are an attractive alternative to liver biopsy because of price that suits both the patient and clinician. In addition to that this method is almost non-invasive to assess liver fibrosis with a small number of diagnostic errors, can be used in the dynamics which allows to monitor the level of fibrosis.
Medical academic journal. 2014;14(1):16-23
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MOLECULAR BASIS OF β2-MICROGLOBULIN AMYLOIDOSIS
Polyakov D.S., Shavlovsky M.M.

Abstract

Beta2-microglobulin am yloidosis (Aβ2M -amyloidosis) - is complication of chronic hemodialysis, resulting from accumulation of amyloid deposits in the patient’s tissues. The major component of the amyloid is presented by beta2-microglobulin (β2M) fibrils. Normally β2M is excreted by kidneys, but in patients with end-stage renal disease β2M concentration is continuously increased due to impaired renal excretion. High β2M serum concentration is necessary but not sufficient for the development of Aβ2M-amyloidosis. Other factors resulting in the β2M polymerization and the deposition of amyloid fibrils are not clear, and in present time they the subject of in vivo and in vitro studies. Despite the clinical importance and fairly high incidence of this disease, in Russian literature these issue is gaining very little attention. In particular, we do not know works, descriding in detail the molecular aspect of the Aß2M amyloidosis. In this review, we have attempted to summarize the literature data and the results obtained in our laboratory regarding to the biochemical processes underlying the abnormal fibrilogenesis of β2M. Individually it is written about the problems of in vitro simulation, diagnosis, and immunological aspects of the disease. The clinical manifestations of Aβ2M amyloidosis are briefly summarized.
Medical academic journal. 2014;14(1):24-41
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MECHANISMS OF LONG TERM POTENTIATION IMPAIRMENT IN ALZHEIMER’S DESEASE
Mukhin V.N., Klimenko V.M.

Abstract

Long term potentiation of synaptic strength (LTP) is an important neurophysiological mechanism of formation of declarative memory engram. Declarative memory disorder is a genuine symptom and obligate diagnostic criterion of Alzheimer’s disease. Che of pathophysiological components of such disorder is NMDA-dependent LTP impairment. To date, the scientific literature has accumulated data on the pathogenetic mechanisms of this impairment. Further study of pathogenesis of the declarative memory disorder in Alzheimer’s desease and development of ways to treat the disease requires summarizing of the data. This is the purpose of this literature review.
Medical academic journal. 2014;14(1):42-51
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EXPERIMENTAL ACUTE STRESS AND MYOCARDIAL PROFIBROTIC PROCESS
Veber V.R., Rubanova M.P., Zhmailova S.V., Gubskaya P.M., Karev V.E., Rumyantsev Y.Y., Kulik N.A., Sulimanova D.R.

Abstract

This research investigates particularities of myocardial fibrogenesis following experimental adrenergic and cholinergic stress. The experiment used 2 series of Wistar rats (20 rats in a serie). 2 hours and 1 month after injection of medicament extracellular space density, collagen density; FGF-2, TGF-β1 cellular and endothelial expression was studied in right and left ventricle’s myocardium. Myocardial collagen density was significantly elevated both 2 hours and 1 month compared to intact animals following acute stress (both adrenergic and cholinergic variant). FGF-2 cellular expression was approximately the same 2 hours and 1 month following both stress variants. TGF-β1 cellular expression was significantly higher following cholinergic stress, than TGF-β1 expression following adrenergic stress (both 2 hours and 1 month after). Therefore, this findings may indicate that myocardial fibrogenesis following cholinergic stress proceeds more actively during first hours and persists 1 month after acute cholinergic stress (supported by prolonged TGF-β cellular expression). In our opinion, acute stress activates profibrotic process, wich, once initiated, could become self-supporting.
Medical academic journal. 2014;14(1):52-57
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NEUROPHYSIOLOGIC MECHANISMS OF DEVELOPMENT AND COMPENSATION OF PSYCHO-EMOTIONAL DISORDERS IN ADOLESCENTS WITH FIRST EPISODE OF LESS-PROGREDIENT SCHIZOPHRENIA
Yakovlev N.M., Slezin V.B.

Abstract

Using systemic approach, neurophysiologic and biochemical mechanisms of development of personality disorders and behavior in adolescent with schizophrenia were analyzed. The different forms of less-progredient schizophrenia were studied - schizotypic disorder (F21.0 according MKB-10), pseudopsychopathic and pseudoneurotic disorders, schizoaffective psychoses, ordinary and paranoid forms of schizophrenia. The effectiveness of functional correction these disorders (convertibility) based on the method of adaptive selfregulation of functional state with biofeedback (AS-BFB). The psychophysiological substantiation of the concept of the development of schizophrenia is suggested.
Medical academic journal. 2014;14(1):58-65
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ROLE OF WEATHER FACTORS IN CHANGE OF THE PSYCHOPHYSIOLOGICAL CONDITION OF THE HEALTHY PERSON AND THE ISCHEMIC HEART DISEASE PATIENT, THE SUN ARISING AT INFLUENCE
Kameneva E.G., Sofronov G.A., Zhirkov A.M.

Abstract

The purpose of the given work was studying of physiological indicators and psychological characteristics of healthy people and CAD patients in low activity of the Sun. During research following methods of an estimation have been used: in dynamics arterial pressure (AP) was registered. Results of unitary measurement the AP were compared with its results daily monitorings. For a communication estimation between a condition of mental health and diseases of cardiovascular system the indicator «haemodynamic potential» (Wr) was used. The psychophysiological condition was estimated psychological techniques of test Lusher and a questionnaire the «state of health, activity and mood». The correlation analysis of physiological and psychological indicators with parametres of solar activity days and hours of carrying out of inspection of patients was carried out. Researches have shown, that indicators of haemodynamics and the psychophysiological indicators received by us at healthy and sick CAD have various degree of correlation with helio-geomagnetic parametres in low solar activity.
Medical academic journal. 2014;14(1):66-73
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PREVENTIVE ASPECTS OF PRENOSLOGICAL APPROACH TO INTERNAL MEDICINE
Shemerovskii K.A., Ovsyannikov V.I.

Abstract

The significance of prenosological approach to the prevention of many internal diseases is represented. Attention is focused on the essential preventive orientation of this approach, which prevents the emergence of many diseases. Prenosological approach can directly reduce incidence and mortality from many diseases. There are two main range of diseases (intestinal and extra intestinal pathology), which may be prevented using prenosological approach. Attention is paid to chronophysiological aspect of prenosological approach, allowing elimination of the functional deviations from circadian intestine rhythm. Early recovery of the regularity of the circadian rhythm of the intestine can help prevention of the occurrence of the intestinal pathology: ulcerative colitis and Crohn’s disease, diverticular and hemorrhoid diseases, polyps, colon cancer, and colorectal cancer. Prenosological approach also aims to prevent the emergence of the extra intestinal pathology: obesity and metabolic syndrome, hypertension and atherosclerosis, cholelithiasis and varicose veins.
Medical academic journal. 2014;14(1):74-79
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ANALYSIS OF LACTOFERRIN CONCENTRATION AND IRON/COPPER SATURATION IN BREAST MILK WOMEN FROM DAY 1 TO 5 YEARS OF LACTATION
Kostevich V.A., Sokolov A.V., Zakharova E.T., Vasilyev V.B.

Abstract

Breast feeding of children older than one year is widely discussed in pediatric circles. Our aim was to study the concentrations of lactoferrin (LF) and its saturation with iron and copper in breast milk of women residing in Saint-Petersburg. Fifteen women that kept lactating for 2 years voluntarily provided samples of breast milk (over 7000 samples) in which LF was assayed. LF concentration was measured in 384 samples (100 ml) of breast milk and, upon the protein’s isolation, its saturation with iron and copper were established. Saturation of LF with iron and copper varied from 6 to 9% and from 2 to 3%, respectively. During the first week of lactation LF content in colostrum was 2-8 mg/ml, after which its concentration decreased gradually to 0,5-2,0 mg/ml by the end the 12th month. During the next 12 months it was 0,5-1,0 mg/ml. Only 24 samples were obtained from women lactating over 2 years, the longest term being 5 years. LF content in those samples was 2-5 mg/ml, which resembled colostrum. Considering average amounts of breast milk fed by lactating women to their children, a rough estimate shows that a child receives over 50 mg LF daily, which is close to curative doses of LF used in treatment of patients with tumors. Our results call in question the viewpoint, widely accepted by pediatricians of St.-Petersburg, i.e. that after the first year of lactation breast milk contains no valuable components.
Medical academic journal. 2014;14(1):80-86
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PECULIARITIES OF IMMUNE STATUS AT HIGH PHYSICAL ACTIVITY AND APPLICATION SYSTEMIC ENZYME
Sternin Y.I., Siziakina L.P.

Abstract

Breakdown of systems of adaptation in the training processes leads to increased increased morbidity and deterioration of performance. Stress immunodeficiency develop himself in sportsmen of high qualification, is one of the mechanisms of breakdown of systems of adaptation. The use of polyenzyme preparation Wobenzym in highly-skilled athletes proved to be quite effective for the treatment of general adaptation syndrome, which resulted in reduction of the number of skipped training, reducing the number of days of incapacity, increasing efficiency, accelerate the course of regenerative processes.
Medical academic journal. 2014;14(1):87-92
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SPEECH OF PROFESSOR CLEARY P.PATRICK REGARDING THE PRESENTATION OF THE MANTLE OF HONORARY DOCTOR OF THE RESEARCH INSTITUTE OF EXPERIMENTAL MEDICINE RAMS
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Abstract

Medical academic journal. 2014;14(1):93-96
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OBShchEE SOBRANIE SEVERO-ZAPADNOGO OTDELENIYa RAMN, SANKT-PETERBURG 27 yanvarya 2014 g
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Abstract

Medical academic journal. 2014;14(1):97-98
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MEDICAL TRAINING IN CLASSIC UNIVERSITY
Veber V.R.

Abstract

Medical academic journal. 2014;14(1):99-100
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STATUS AND PROSPECTIVES OF INTERACTION BETWEEN UNIVERSITIES AND SCIENTIFIC CENTERS IN MEDICAL EDUCATION SYSTEM
Bagnenko S.F., Belyakov N.A., Trofimova T.N.

Abstract

Medical academic journal. 2014;14(1):101-103
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Nauchno-prakticheskiy simpozium «VICh-infektsiya i virusnye gepatity»
Rassokhin V.V., Toropov S.E., Zholobov E.V.

Abstract

Medical academic journal. 2014;14(1):104-109
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K YuBILEYu PROFESSORA IVANA PETROVIChA DUDANOVA
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Abstract

Medical academic journal. 2014;14(1):110-111
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