BETULENOL DERIVATIVES AS POTENTIAL ANTI-HIV AGENTS

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Abstract


In this review, the important advances in the study of anti-HIV activity of betulenol, its natural and semisynthetic analogues obtained since 1993 are described. The perspective structures with potent anti-HIV activity are demonstrated. The structure-activity relationships of the obtained compounds are discussed. The latest trends in the development of anti-HIV agents based on the chemical modification of betulenol are underlined. The mechanisms of action of the most important agents are summarized in the review. Betulenol derivatives should be considered as a new effective class of specific inhibitors of HIV.

A Z Abyshev

Email: azabyshev@mail.ru

R A Abyshev

V H Nguyen

V A Morozova

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